Title:
MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/154813
Kind Code:
A1
Abstract:
The present invention provides monoclonal antibodies that specifically bind
to the hemagglutinin (HA) of avian influenza virus subtype H5, as well as monoclonal
antibodies capable of blocking at least 50% of the HA binding activity of these
monoclonal antibodies. Such monoclonal antibodies are useful in the detection,
diagnosis, prevention and treatment of avian influenza virus, especially avian
influenza virus subtype H5. The present invention also provides hybridoma cell
lines, isolated nucleic acid molecules, and short peptides related to the monoclonal
antibodies provided herein, and pharmaceutical compositions, medical diagnostic
apparatuses and kits containing the monoclonal antibodies provided herein.
Inventors:
CHEN YIXIN (CN)
LUO WENXIN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
GUAN YI (CN)
CHEN HONGLIN (CN)
LUO WENXIN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
GUAN YI (CN)
CHEN HONGLIN (CN)
Application Number:
PCT/CN2008/001153
Publication Date:
December 24, 2008
Filing Date:
June 16, 2008
Export Citation:
Assignee:
UNIV XIAMEN (CN)
YANG SHENG TANG CO LTD (CN)
CHEN YIXIN (CN)
LUO WENXIN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
GUAN YI (CN)
CHEN HONGLIN (CN)
YANG SHENG TANG CO LTD (CN)
CHEN YIXIN (CN)
LUO WENXIN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
GUAN YI (CN)
CHEN HONGLIN (CN)
International Classes:
C07K16/18; A61K38/08; A61K38/10; A61K39/395; A61P31/16; C07K7/06; C07K7/08; C07K16/46; C12N5/12; C12N15/13; C12N15/63; G01N33/53; G01N33/569; C07K14/11
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GUO YUANJI, CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY, no. 3, 2004
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SHAFER, AL ET AL., AVIAN DIS., vol. 42, no. 1, 1998, pages 28 - 34
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"CURRENT PROTOCOLS IN IMMUNOLOGY", 1999
SCHAAF ET AL., LANGMUIR, vol. 3, 1987, pages 1131 - 1135
KIM, MACROMOLECULES, vol. 22, 1984, pages 2682 - 2685
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KABAT EA; WU TT; PERRY HM; GOTTESMAN KS; COELLER K.: "Sequences of proteins of immunological interest", 1991, NIH
See also references of EP 2174957A4
QIN A.J. ET AL.: "Development and application of monoclonal antibodies specific the hemagglutinin of subtype H5 and H9 avian influenza virus", CHINESE JOURNAL OF PREVENTIVE VETERINARY MEDICINE, vol. 25, no. 3, May 2003 (2003-05-01), pages 161 - 163, XP001525450
CAO Z. ET AL.: "Preparation and characterization of monoclonal antibody specific to hemagglutinin of subtype H5 avian influenza virus", ACTA LAB ANIM. SCI. SIN., vol. 12, no. 4, December 2004 (2004-12-01), pages 197 - 199
LUO H.F. ET AL.: "Characterization of broad-spectrum neutralization monoclonal antibody against haemagglutinin of H5 subtype avian influenza virus", CHINESE JOURNAL OF VIROLOGY, vol. 23, no. 2, March 2007 (2007-03-01), pages 85 - 90, XP001525197
MATROSOVICH, M. ET AL., J VIROL, vol. 73, no. 2, 1999, pages 1146 - 55
CAUTHEN, A.N. ET AL., J VIROL., vol. 74, no. 14, 2000, pages 6592 - 9
WEBSTER, R.G. ET AL., J VIROL., vol. 76, no. 1, 2002, pages 118 - 26
GUAN, Y ET AL., PROC NATL ACAD SCI U S A, vol. 99, no. 13, 2002, pages 8950 - 5
GUAN, Y ET AL., PROC NATL ACAD SCI U S A, vol. 101, no. 21, 2004, pages 8156 - 61
STURM-RAMIREZ, K.M. ET AL., J VIROL., vol. 78, no. 9, 2004, pages 4892 - 901
PEIRIS, JS ET AL., LANCET, vol. 363, no. 9409, 2004, pages 617 - 9
GUAN, Y ET AL., PROC NATL ACAD SCI USA, vol. 101, no. 21, 2004, pages 8156 - 61
THANAWONGNUWECH, R. ET AL., EMERG INFECT DIS, vol. 11, no. 5, 2005, pages 699 - 701
UNGCHUSAK, K. ET AL., N ENGL J MED, vol. 352, no. 4, 2005, pages 333 - 40
HIEN , T.T. ET AL., N ENGL J MED, vol. 351, no. 23, 2004, pages 2363 - 5
STOHR, K. ET AL., N ENGL J MED, vol. 352, no. 4, 2005, pages 405 - 7
HORIMOTO T. ET AL., TRENDS IN MOLECULAR MEDICINE, vol. 12, no. 11, 2006, pages 506 - 514
MONTO, AS, VACCINE, vol. 21, no. 16, 2003, pages 1796 - 800
DOLIN, R. ET AL., N ENGL J MED, vol. 307, no. 10, 1982, pages 580 - 4
SHIRAISHI, K. ET AL., J INFECT DIS, vol. 188, no. 1, 2003, pages 57 - 61
BRIGHT, R.A. ET AL., LANCET, vol. 366, no. 9492, 2005, pages 1175 - 81
TSIODRAS, S. ET AL., BMJ, vol. 334, no. 7588, 2007, pages 293 - 4
LE, Q.M. ET AL., NATURE, vol. 437, 2005, pages 1108
DE JONG, M.D. ET AL., ENGL JMED., vol. 353, 2005, pages 2667 - 2672
DE JONG, M.D. ET AL., NAT MED., vol. 12, 2006, pages 1203 - 1207
SAWYER, L.A., ANTIVIRAL RES., vol. 47, 2000, pages 57 - 77
LUKE, T.C. ET AL., ANN INTERN MED., vol. 145, 2006, pages 599 - 609
LU, J. ET AL., RESPIR RES., vol. 7, 2006, pages 43
SIMMONS, C.P. ET AL., PLOS MEDICINE, vol. 4, no. 5, 2007, pages 928 - 936
HANSON, B.J. ET AL., RESPIR RES., vol. 7, 2006, pages 126
QIN AIJIAN; SHAO HONGXIA; QIAN XIAN ET AL., JOURNAL OF CHINESE PREVENTION VETERINARY MEDICINE, no. 3, 2003
GUO YUANJI, CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY, no. 3, 2004
ROWE T ET AL., J CLIN MICROBIOL., vol. 37, no. 4, April 1999 (1999-04-01), pages 937 - 43
ZHOU EM ET AL., AVIAN DIS., vol. 42, no. 4, 1998, pages 757 - 61
SHAFER, AL ET AL., AVIAN DIS., vol. 42, no. 1, 1998, pages 28 - 34
LU H., AVIAN DIS., vol. 47, no. 2, 2003, pages 361 - 9
SALA G; CORDIOLI P; MORENO-MARTIN ET AL., AVIAN DIS., vol. 47, no. 3, 2003, pages 1057 - 9
KABAT ET AL.: "Proteins of Immunological Interest", vol. 1-3, 1991, NIH PUBLICATION, pages: 91 - 3242
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
CABILLY; MORRISON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
JONES ET AL., NATURE, vol. 321, 1986, pages 522 525
REICHMANN ET AL., NATURE, vol. 332, 1988
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 402
GODING: "Monoclonal Antibodies: Principles and Practice", 1996, ACADEMIC PRESS, pages: 59 103
KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001
BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63
MUNSON ET AL., ANAL. BIOCHEM., vol. 107, 1980, pages 220
MORIMOTO ET AL., J. BIOCHEM. BIOPHYS. METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
HUDSON, CURR. OPIN. IMMUNOL., vol. 11, 1999, pages 548 - 557
LITTLE ET AL., IMMUNOL. TODAY, vol. 21, 2000, pages 364 - 370
CARTER ET AL., BIO/TECHNOLOGY, vol. 10, 1992, pages 163 167
"Principles of Fluorescence Spectroscopy", July 1999, PLENUM PUB CORP
RICHARD P. HOAGLAND: "Molecular Probes Handbook"
HUHTINEN ET AL., CLIN. CHEM., vol. 50, no. 10, October 2004 (2004-10-01), pages 1935 - 6
J. BIOCHEM., vol. 79, 1976, pages 233
J. AM. CHEM. SOC., vol. 100, 1978, pages 3585
TAEWOON CHA ET AL., PROTEOMICS, vol. 5, 2005, pages 416 - 419
SHAWN WENG ET AL., PROTEOMICS, vol. 2, 2002, pages 48 - 57
SOELLNER, M. ET AL., J. AM. CHEM. SOC., vol. 125, 2003, pages 11790 - 11791
HAIRONG ZHANG ET AL., ANAL. CHEM, vol. 78, 2006, pages 609 - 616
HAI XU ET AL., J. PHYS. CHEM., vol. 110, 2006, pages 1907 - 1914
SEUNG-YONG SEONG ET AL., PROTEOMICS, vol. 3, 2003, pages 2176 - 2189
SERCEL, J. ET AL., SPIE PROCEEDINGS, vol. 998, September 1988 (1988-09-01)
DUDLEY, B. S., J. CLIN. IMMUNOASSAY, vol. 14, no. 2, 1991, pages 77
"CURRENT PROTOCOLS IN IMMUNOLOGY", 1999
SCHAAF ET AL., LANGMUIR, vol. 3, 1987, pages 1131 - 1135
KIM, MACROMOLECULES, vol. 22, 1984, pages 2682 - 2685
EKINS ET AL., CLINICA CHIMICA ACTA., vol. 194, 1990, pages 91 - 114
ANAL. BIOCHEM, vol. 150, 1985, pages 449 - 456
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
CHEN ET AL., PNAS, vol. 103, 2006, pages 2845
HULSE-POST ET AL., PNAS, vol. 102, 2005, pages 10682 - 7
KABAT EA; WU TT; PERRY HM; GOTTESMAN KS; COELLER K.: "Sequences of proteins of immunological interest", 1991, NIH
See also references of EP 2174957A4
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