Title:
MONOCLONAL ANTIBODIES SPECIFIC FOR BETA-AMYLOID.
Document Type and Number:
WIPO Patent Application WO2003039467
Kind Code:
A3
Abstract:
This invention provides methods and compositions for the detection, diagnosis and treatment of amyloid-associated diseases, in particular, diseases comprising deposition of amyloid assemblies, fibrils, filaments, tangles, or plaques. A preferred composition comprises monoclonal antibodies that specifically bind amyloid proteins, peptides or fragments and change the conformation.
Inventors:
NICOLAU YVES CLAUDE (US)
GREFERATH RUTH (DE)
GREFERATH RUTH (DE)
Application Number:
PCT/US2002/035444
Publication Date:
October 30, 2003
Filing Date:
November 04, 2002
Export Citation:
Assignee:
DIAGENICS INTERNAT CORP (US)
NICOLAU YVES CLAUDE (US)
GREFERATH RUTH (DE)
NICOLAU YVES CLAUDE (US)
GREFERATH RUTH (DE)
International Classes:
C07K16/18; (IPC1-7): C07K16/00; A61K39/395; C12N5/00; C12N5/06; C12N5/12; C12P21/00
Foreign References:
| US6214565B1 | 2001-04-10 | |||
| US20020086847A1 | 2002-07-04 | |||
| US20020136718A1 | 2002-09-26 |
Other References:
ROHN T.T. ET AL.: "A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis", JOURNAL OF NEUROCHEMISTRY, vol. 74, no. 6, June 2000 (2000-06-01), pages 2331 - 2342, XP002964850
MATUSANA Y. ET AL.: "A pH-dependent conformational transition of abeta peptide and physiochemical properties of the conformers in the glial cell", BIOCHEM. J., vol. 361, 1 February 2002 (2002-02-01), pages 547 - 556, XP002964851
SUDO H. ET AL.: "Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 16, no. 6, December 2000 (2000-12-01), pages 708 - 723, XP002964852
MATUSANA Y. ET AL.: "A pH-dependent conformational transition of abeta peptide and physiochemical properties of the conformers in the glial cell", BIOCHEM. J., vol. 361, 1 February 2002 (2002-02-01), pages 547 - 556, XP002964851
SUDO H. ET AL.: "Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein", MOLECULAR AND CELLULAR NEUROSCIENCE, vol. 16, no. 6, December 2000 (2000-12-01), pages 708 - 723, XP002964852
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