Title:
MONOCLONAL ANTIBODIES SPECIFICALLY FOR PHOSPHOPROTEIN OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS AND THE METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2017/021815
Kind Code:
A3
Abstract:
The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. The invention provides also diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, comprising the antibodies produced by the mentioned hybridomas.
Inventors:
BUENO RAMÍREZ SUSAN MARCELA (CL)
KALERGIS PARRA ALEXIS MIKES (CL)
MORA ALARCÓN JORGE EUGENIO (CL)
KALERGIS PARRA ALEXIS MIKES (CL)
MORA ALARCÓN JORGE EUGENIO (CL)
Application Number:
PCT/IB2016/054424
Publication Date:
May 11, 2017
Filing Date:
July 25, 2016
Export Citation:
Assignee:
PONTIFICIA UNIV CATÓLICA DE CHILE (CL)
International Classes:
C07H21/04; C12P21/08; C12Q1/70; G01N33/53
Domestic Patent References:
| WO1996016974A1 | 1996-06-06 |
Foreign References:
| US20100278813A1 | 2010-11-04 | |||
| US20110287444A1 | 2011-11-24 | |||
| US20130266600A1 | 2013-10-10 | |||
| US20140348858A1 | 2014-11-27 |
Other References:
LU ET AL.: "The Major Phosphorylation Sites of the Respiratory Syncytial Virus Phosphoprotein Are Dispensable for Virus Replication In Vitro.", J VIROL., vol. 76, no. 21, 2002, pages 10776 - 84, XP002489806
Attorney, Agent or Firm:
CLARKE, MODET & CO. CHILE (CL)
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