Title:
MONOCLONAL ANTIBODIES TARGETING AMYLOID BETA OLIGOMERS
Document Type and Number:
WIPO Patent Application WO/2011/151076
Kind Code:
A3
Abstract:
The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Αβ starting with pyroglutamate (ΑβρΕ), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Αβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM ACC3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said ΑβρΕ oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Αβ oligomers in a subject.
Inventors:
BAYER THOMAS (DE)
WIRTHS OLIVER (DE)
MARTENS HENRIK (DE)
ERCK CHRISTIAN (DE)
WIRTHS OLIVER (DE)
MARTENS HENRIK (DE)
ERCK CHRISTIAN (DE)
Application Number:
PCT/EP2011/002739
Publication Date:
February 02, 2012
Filing Date:
June 03, 2011
Export Citation:
Assignee:
GEORG AUGUST UNI GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN (DE)
SYNAPTIC SYSTEMS GES FUER NEUROBIOLOGISCHE FORSCHUNG ENTWICKLUNG UND PRODUKTION MBH (DE)
BAYER THOMAS (DE)
WIRTHS OLIVER (DE)
MARTENS HENRIK (DE)
ERCK CHRISTIAN (DE)
SYNAPTIC SYSTEMS GES FUER NEUROBIOLOGISCHE FORSCHUNG ENTWICKLUNG UND PRODUKTION MBH (DE)
BAYER THOMAS (DE)
WIRTHS OLIVER (DE)
MARTENS HENRIK (DE)
ERCK CHRISTIAN (DE)
International Classes:
C07K16/18; A61K39/395; A61P25/28; G01N33/577
Domestic Patent References:
| WO2006014478A1 | 2006-02-09 | |||
| WO2009149486A2 | 2009-12-17 |
Foreign References:
| US20100021478A1 | 2010-01-28 |
Other References:
WIRTHS OLIVER ET AL: "Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 31 DEC 2010 LNKD- PUBMED:20971852, vol. 285, no. 53, 31 December 2010 (2010-12-31), pages 41517 - 41524, XP002658320, ISSN: 1083-351X
CHAUHAN NEELIMA B ET AL: "Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Abeta antibody into the third ventricle of TgCRND8 mice.", JOURNAL OF NEUROSCIENCE RESEARCH 1 DEC 2004 LNKD- PUBMED:15478192, vol. 78, no. 5, 1 December 2004 (2004-12-01), pages 732 - 741, XP002658321, ISSN: 0360-4012
ACERO G ET AL: "Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits", JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, XX, vol. 213, no. 1-2, 18 August 2009 (2009-08-18), pages 39 - 46, XP002605076, ISSN: 0165-5728, [retrieved on 20090709], DOI: 10.1016/J.JNEUROIM.2009.06.003
CHAUHAN NEELIMA B ET AL: "Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Abeta antibody into the third ventricle of TgCRND8 mice.", JOURNAL OF NEUROSCIENCE RESEARCH 1 DEC 2004 LNKD- PUBMED:15478192, vol. 78, no. 5, 1 December 2004 (2004-12-01), pages 732 - 741, XP002658321, ISSN: 0360-4012
ACERO G ET AL: "Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits", JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, XX, vol. 213, no. 1-2, 18 August 2009 (2009-08-18), pages 39 - 46, XP002605076, ISSN: 0165-5728, [retrieved on 20090709], DOI: 10.1016/J.JNEUROIM.2009.06.003
Attorney, Agent or Firm:
WICHMANN, Hendrik (Schweigerstr. 2, München, DE)
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