Title:
MONOCLONAL ANTIBODY AGAINST HUMAN PRPC AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/172708
Kind Code:
A1
Abstract:
Provided is a monoclonal antibody against human PrPc protein capable of reducing the expression level of transcription factor Twist1 in a targeting mode and inducing macrophage and NK cells to target to rectal cancer tumor cells. The tumor inhibitory effect of the combination drug therapy with the antibody and cetuximabis also better than that of a single use of the antibody or cetuximab.
Inventors:
CHEN QUAN (CN)
LI BAOWEI (CN)
HANG HAIYING (CN)
DU LEI (CN)
WANG JUN (CN)
WANG XIAOHUI (CN)
LI BAOWEI (CN)
HANG HAIYING (CN)
DU LEI (CN)
WANG JUN (CN)
WANG XIAOHUI (CN)
Application Number:
PCT/CN2015/078775
Publication Date:
November 19, 2015
Filing Date:
May 12, 2015
Export Citation:
Assignee:
INST ZOOLOGY CAS (CN)
CHEN QUAN (CN)
LI BAOWEI (CN)
HANG HAIYING (CN)
DU LEI (CN)
WANG JUN (CN)
WANG XIAOHUI (CN)
CHEN QUAN (CN)
LI BAOWEI (CN)
HANG HAIYING (CN)
DU LEI (CN)
WANG JUN (CN)
WANG XIAOHUI (CN)
International Classes:
A61K39/395; C07K16/18; A61P35/00; C12N15/13; G01N33/577
Foreign References:
| CN103013927A | 2013-04-03 | |||
| CN104031148A | 2014-09-10 | |||
| CN101550186A | 2009-10-07 |
Attorney, Agent or Firm:
BEIJINGCHENGHUI LAW FIRM (CN)
北京市诚辉律师事务所 (CN)
北京市诚辉律师事务所 (CN)
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