Title:
MONOCLONAL ANTIBODY AGAINST NECROSIS MARKER ERp29 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/111698
Kind Code:
A1
Abstract:
Disclosed is a monoclonal antibody against a biomarker capable of highly specific and effective use in the detection and diagnosis of various pathologies associated with various types of cancer nests and necrotic focuses. The monoclonal antibody against necrosis markers comprises (1) any of the amino acid sequences shown in sequences #1-3, or (2) an amino acid sequence of (1) having one or multiple amino acids substituted, deleted or inserted, or an amino acid sequence at least 90%, preferably at least 95%, or more preferably at least 98%, homologous with the amino acid sequences of (1), and which as a protein displays the same function, activity or properties of the amino acid sequences in (1).
Inventors:
SUGANO SUMIO (JP)
KANZAKI YUKARI (JP)
SAGA TSUNEO (JP)
TSUJI ATSUSHI (JP)
KANZAKI YUKARI (JP)
SAGA TSUNEO (JP)
TSUJI ATSUSHI (JP)
Application Number:
PCT/JP2011/055365
Publication Date:
September 15, 2011
Filing Date:
March 08, 2011
Export Citation:
Assignee:
SUGANO SUMIO (JP)
KANZAKI YUKARI (JP)
SAGA TSUNEO (JP)
TSUJI ATSUSHI (JP)
KANZAKI YUKARI (JP)
SAGA TSUNEO (JP)
TSUJI ATSUSHI (JP)
International Classes:
C07K16/18; A61K39/395; A61K45/00; A61K49/00; A61K51/00; A61P9/00; A61P9/10; A61P35/00; C12Q1/02; C12Q1/68; G01N33/53; A61P1/16; A61P1/18; A61P21/00; C12N15/09
Domestic Patent References:
| WO2007085411A1 | 2007-08-02 | |||
| WO2000001822A1 | 2000-01-13 | |||
| WO2003016910A1 | 2003-02-27 |
Foreign References:
| JP2733658B2 | 1998-03-30 | |||
| JP3190042B2 | 2001-07-16 | |||
| JP2002519065A | 2002-07-02 | |||
| JP2008014937A | 2008-01-24 |
Other References:
CHANDRA H. ET AL.: "Proteome analysis of mouse macrophages treated with anthrax lethal toxin.", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMIC, vol. 1747, 2005, pages 151 - 159, XP027627689
ZHANG B. ET AL.: "ERp29 is a radiation- responsive gene in IEC-6 cell.", JOURNAL OF RADIATION RESEARCH, vol. 49, 2008, pages 587 - 596
BAMBANG IF. ET AL.: "Overexpression of endoplasmic reticulum protein 29 regulates mesenchymal-epithelial transition and suppresses xenograft tumor growth of invasive breast cancer cells.", LABORATORY INVESTIGATION, vol. 89, 2009, pages 1229 - 1242, XP055072073
See also references of EP 2546266A4
LIN JF; XU J; TIAN HY; GAO X; CHEN QX; GU Q; XUGJ; SONG JD; ZHAO FK, INT. J. CANCER, vol. 121, no. 12, 15 December 2007 (2007-12-15), pages 2596 - 605
CHEN G; GHARIB TG; HUANG CC; THOMAS DG; SHEDDEN KA; TAYLOR JM; KARDIA SL; MISEK DE; GIORDANO TJ; IANNETTONI MD, CLIN. CANCER RES., vol. 8, no. 7, July 2002 (2002-07-01), pages 2298 - 305
KARLIN; ALTSHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
TATIANA A.; TATUSOVA ET AL., FEMS MICROBIOL. LETT., vol. 174, 1999, pages 247 - 250
W.R. PEARSON; D.J. LIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
NAGAMUNE H.; TERADA H.: "Monoclonal Antibody", 1990, HIROKAWA PUBLISHING CO.
JAMES W. GODING: "Monoclonal Antibody", 1996, ACADEMIC PRESS
ZHANG B. ET AL.: "ERp29 is a radiation- responsive gene in IEC-6 cell.", JOURNAL OF RADIATION RESEARCH, vol. 49, 2008, pages 587 - 596
BAMBANG IF. ET AL.: "Overexpression of endoplasmic reticulum protein 29 regulates mesenchymal-epithelial transition and suppresses xenograft tumor growth of invasive breast cancer cells.", LABORATORY INVESTIGATION, vol. 89, 2009, pages 1229 - 1242, XP055072073
See also references of EP 2546266A4
LIN JF; XU J; TIAN HY; GAO X; CHEN QX; GU Q; XUGJ; SONG JD; ZHAO FK, INT. J. CANCER, vol. 121, no. 12, 15 December 2007 (2007-12-15), pages 2596 - 605
CHEN G; GHARIB TG; HUANG CC; THOMAS DG; SHEDDEN KA; TAYLOR JM; KARDIA SL; MISEK DE; GIORDANO TJ; IANNETTONI MD, CLIN. CANCER RES., vol. 8, no. 7, July 2002 (2002-07-01), pages 2298 - 305
KARLIN; ALTSHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
TATIANA A.; TATUSOVA ET AL., FEMS MICROBIOL. LETT., vol. 174, 1999, pages 247 - 250
W.R. PEARSON; D.J. LIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444 - 2448
NAGAMUNE H.; TERADA H.: "Monoclonal Antibody", 1990, HIROKAWA PUBLISHING CO.
JAMES W. GODING: "Monoclonal Antibody", 1996, ACADEMIC PRESS
Attorney, Agent or Firm:
ABE MASAHIRO (JP)
Masahiro Abe (JP)
Masahiro Abe (JP)
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