Title:
MONOCLONAL ANTIBODY BINDING TO HUMAN IL-5, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/120060
Kind Code:
A1
Abstract:
Disclosed is a monoclonal antibody that binds to human IL-5. The monoclonal antibody that binds to human IL-5 has a good biological activity for inhibiting TF-1 cell proliferation induced by IL-5 and blocking the interaction between IL-5 and IL-5RA, has a different antigen epitope from the known anti-human IL-5 antibody, can be used for preparing drugs for treating diseases mediated by the over-expression of eosinophilic granulocytes (such as asthma), and has a good clinical application prospect.
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Inventors:
ZHAO JIE (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
JIANG LIANGFENG (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
JIANG LIANGFENG (CN)
Application Number:
PCT/CN2018/118534
Publication Date:
June 27, 2019
Filing Date:
November 30, 2018
Export Citation:
Assignee:
SUNSHINE GUOJIAN PHARMACEUTICAL SHANGHAI CO LTD (CN)
International Classes:
C07K16/24; C12N15/02; C12N15/12; A61K39/395; C12N5/10; C12N15/63; C12P21/08; G01N33/53
Domestic Patent References:
| WO2010136483A2 | 2010-12-02 |
Foreign References:
| CN103429261A | 2013-12-04 | |||
| CN101848732A | 2010-09-29 | |||
| CN1656122A | 2005-08-17 | |||
| CN1189190A | 1998-07-29 | |||
| PT1527100E | 2009-08-25 | |||
| US9505826B2 | 2016-11-29 |
Other References:
HART T KCOOK R MZIAAMIRHOSSEINI P ET AL.: "Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys[J", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 108, no. 2, 2001, pages 250 - 257, XP002577858, DOI: 10.1067/MAI.2001.116576
EGAN R WATHWAL DBODMER M W ET AL.: "Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity[J", ARZNEIMITTELFORSCHUNG, vol. 49, no. 09, 1999, pages 779 - 790
ORTEGA HLIU M CPAVORD I D ET AL.: "Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma[J", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 371, no. 13, 2014, pages 1198 - 1207, XP055317697, DOI: 10.1056/NEJMoa1403290
BJERMER LLEMIERE CMASPERO J F ET AL.: "Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study[J", CHEST, vol. 150, no. 4, 2016, pages 789 - 798
SAMBROOK, J.FRITSCHMANIAIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Antibody Engineering", vol. 1, pages: 323
See also references of EP 3730518A4
EGAN R WATHWAL DBODMER M W ET AL.: "Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity[J", ARZNEIMITTELFORSCHUNG, vol. 49, no. 09, 1999, pages 779 - 790
ORTEGA HLIU M CPAVORD I D ET AL.: "Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma[J", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 371, no. 13, 2014, pages 1198 - 1207, XP055317697, DOI: 10.1056/NEJMoa1403290
BJERMER LLEMIERE CMASPERO J F ET AL.: "Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study[J", CHEST, vol. 150, no. 4, 2016, pages 789 - 798
SAMBROOK, J.FRITSCHMANIAIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Antibody Engineering", vol. 1, pages: 323
See also references of EP 3730518A4
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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