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Patent Searching and Data


Title:
MONOCLONAL ANTIBODY SPECIFICALLY REACTING WITH DUPAN-2 ANTIGEN AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/189874
Kind Code:
A1
Abstract:
A conventional antibody recognizing a sugar chain antigen, said sugar chain antigen being to be used as a tumor marker, shows an insufficient antigen specificity. When such an antibody is used in detecting a tumor marker, there arises a problem that the detection specificity is lowered and thus cancer diagnosis accuracy is also lowered. To solve this problem, the present invention provides an antibody that specifically reacts with the sugar chain of DUPAN-2 antigen to be used as a tumor marker and a method for producing the antibody.

Inventors:
MIURA Tomohiro (1-3, Nihonbashi 2-chome, Chuo-k, Tokyo 27, 〒1030027, JP)
MIYAZAKI Osamu (1-3, Nihonbashi 2-chome, Chuo-k, Tokyo 27, 〒1030027, JP)
Application Number:
JP2019/014321
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
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Assignee:
SEKISUI MEDICAL CO., LTD. (1-3 Nihonbashi 2-chome, Chuo-ku Tokyo, 27, 〒1030027, JP)
International Classes:
C07K16/28; C12N5/18; G01N33/53
Domestic Patent References:
WO2017170824A12017-10-05
WO2017146127A12017-08-31
Other References:
TANG, H. ET AL.: "Glycan Motif Profiling Reveals Plasma Sialyl-Lewis X Elevations in Pancreatic Cancers That Are Negative for Sialyl-Lewis A", MOLECULAR & CELLULAR PROTEOMICS, vol. 14, no. 5, 1 May 2015 (2015-05-01), pages 1323 - 1333, XP055639130
RAGUPATHI, G. ET AL.: "Synthesis of sialyl Lewis '' (sLea, CA 19-9) and construction of an immunogenic sLea vaccine", CANCER IMMUNOL. IMMUNOTHER., vol. 58, no. 9, 2009, pages 1397 - 1405, XP019706368
Attorney, Agent or Firm:
ONO Makoto et al. (Anderson Mori & Tomotsune, Otemachi Park Building 1-1-1, Otemach, Chiyoda-ku Tokyo 36, 〒1008136, JP)
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