Title:
MONOCLONAL ANTIBODY SPECIFICALLY RECOGNIZING B-CELL LYMPHOMA CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/133817
Kind Code:
A1
Abstract:
The present invention relates to a monoclonal antibody specifically recognizing B-cell lymphoma cells and a use thereof. Specifically, the present invention relates to the monoclonal antibody; a pharmaceutical composition for preventing or treating B-cell lymphoma, containing the monoclonal antibody; a composition for diagnosing B-cell lymphoma, containing the monoclonal antibody; a method for providing information for the diagnosis of B-cell lymphoma using the monoclonal antibody; a chimeric antigen receptor (CAR) protein comprising 1) the antibody, 2) a transmembrane domain, and 3) an intracellular signaling domain; a recombinant vector expressing the CAR protein; CAR-modified T cells transformed with the recombinant vector; a pharmaceutical composition for preventing or treating B-cell lymphoma, containing the CAR-modified T cells; and an antibody-drug conjugate in which the monoclonal antibody is conjugated with a drug.
Inventors:
KWON BYOUNG SE (KR)
KIM KWANG-HUI (KR)
KIM YOUNG-HO (KR)
OH HO-SIK (KR)
LEE DON-GIL (KR)
LEE SEUNG-JOO (KR)
CHOI BEOM-KYU (KR)
KIM KWANG-HUI (KR)
KIM YOUNG-HO (KR)
OH HO-SIK (KR)
LEE DON-GIL (KR)
LEE SEUNG-JOO (KR)
CHOI BEOM-KYU (KR)
Application Number:
PCT/KR2015/002089
Publication Date:
September 11, 2015
Filing Date:
March 04, 2015
Export Citation:
Assignee:
NAT CANCER CT (KR)
International Classes:
C07K16/28; A61K39/395; G01N33/53
Foreign References:
| KR100701923B1 | 2007-03-30 |
Other References:
AHN, YUN DEOK: "New Monoclonal Antibody that Can Inhibit the Growth of L3055 Burkitt's Lymphoma Cells and HK Follicular Dendritic Cells", MASTER'S THESIS OF SCIENCE OF GRADUATE SCHOOL OF UNIVERSITY OF ULSAN, June 2008 (2008-06-01)
SAVOLDO, B. ET AL.: "CD 28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients", J. CLIN. INVEST., vol. 121, no. 5, 11 April 2011 (2011-04-11), pages 1822 - 1826, XP055204919
VAN MEERTEN, T. ET AL.: "Novel antibodies against follicular non-Hodgkin's lymphoma", BEST PRACT. RES. CLIN. HAEMATOL, vol. 24, no. 2, 5 May 2011 (2011-05-05), pages 231 - 526, XP055222871, ISSN: 1521-6926
HAN, C. ET AL.: "Selective killing of malignant B cells using T cells redirected against malignancy variant receptor", J. IMMUNOTHER. CANCER, vol. 2, no. Suppl. 3, 6 November 2014 (2014-11-06), pages 16, XP021202422, ISSN: 2051-1426
SAVOLDO, B. ET AL.: "CD 28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients", J. CLIN. INVEST., vol. 121, no. 5, 11 April 2011 (2011-04-11), pages 1822 - 1826, XP055204919
VAN MEERTEN, T. ET AL.: "Novel antibodies against follicular non-Hodgkin's lymphoma", BEST PRACT. RES. CLIN. HAEMATOL, vol. 24, no. 2, 5 May 2011 (2011-05-05), pages 231 - 526, XP055222871, ISSN: 1521-6926
HAN, C. ET AL.: "Selective killing of malignant B cells using T cells redirected against malignancy variant receptor", J. IMMUNOTHER. CANCER, vol. 2, no. Suppl. 3, 6 November 2014 (2014-11-06), pages 16, XP021202422, ISSN: 2051-1426
Attorney, Agent or Firm:
LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인리온 (KR)
특허법인리온 (KR)
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