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Title:
MONOMER FOR SYNTHESIS OF RNA, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING RNA
Document Type and Number:
WIPO Patent Application WO/2014/017615
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a monomer for the synthesis of RNA, which can be produced with high efficiency and consequently enables the remarkable reduction in the cost for the production of RNA; a method for producing a monomer for the synthesis of RNA in fewer steps with high efficiency; and a method which can synthesize RNA with high efficiency even when a monomer for the synthesis of the RNA is used in an almost stoichiometric amount. The monomer for the synthesis of RNA according to the present invention is characterized by being represented by formula (I) or (I'). [In the formulae, R1 represents a protective group for a hydroxy group; and R2 represents an alkyl group or the like.]

Inventors:
KATAOKA, Masanori (5-1 Akebonocho 2-chome, Kochi-sh, Kochi 20, 〒7808520, JP)
Application Number:
JP2013/070247
Publication Date:
January 30, 2014
Filing Date:
July 25, 2013
Export Citation:
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Assignee:
KOCHI UNIVERSITY (5-1 Akebonocho 2-chome, Kochi-shi Kochi, 20, 〒7808520, JP)
International Classes:
C07H19/10; C07H19/20; C07H21/02
Domestic Patent References:
WO2011030353A22011-03-17
WO2002079215A12002-10-10
Foreign References:
JP2011512390A2011-04-21
JP2006077013A2006-03-23
JP2011521930A2011-07-28
Other References:
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E. ROZNERS ET AL.: "Synthesis of RNA fragments using the H-phosphonate method and 2'-(2- chlorobenzoyl) protection", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 855 - 857, XP008175985
E. ROZNERS ET AL.: "Evaluation of 2'-hydroxyl protection in RNA-synthesis using the H- phosphonate approach", NUCLEIC ACIDS RESEARCH, vol. 22, no. 1, 1994, pages 94 - 99, XP002919964
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SHOICHIRO OZAKI ET AL.: "Enzyme Aided Regioselective Acylation of Nucleosides", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 401 - 404, XP008175986
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See also references of EP 2878604A4
XIAOHU ZHANG ET AL., TETRAHEDRON LETTERS, vol. 38, no. 41, 1997, pages 7135 - 7138
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (Fujita-Toyobo building 9th floor, 1-16 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, 〒5300003, JP)
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