Title:
MONOSACCHARIDE DERIVATIVES AS ANTI-CANCER AND ANTI-INFLAMMATORY AGENTS
Document Type and Number:
WIPO Patent Application WO2005092907
Kind Code:
A3
Abstract:
The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
Inventors:
SATTIGERI VISWAJANANI JITENDRA (IN)
ARORA SUDERSHAN K (IN)
SALMAN MOHAMMAD (US)
PALLE VENKATA P (IN)
YADAV GYAN CHAND (IN)
TANWAR MADAN PAL (IN)
MUKHERJEE ASHIS (IN)
NARAYANAN RAMAMURTHY (IN)
RAUF ABDUL REHAMAN ABDUL (IN)
NAIK KESHAV PRABHAKAR (IN)
SONI AJAY (IN)
RAY ABHIJIT (IN)
SHIRUMALLA RAJ KUMAR (IN)
MOOKHTIAR KASIM ABBAS (IN)
ARORA SUDERSHAN K (IN)
SALMAN MOHAMMAD (US)
PALLE VENKATA P (IN)
YADAV GYAN CHAND (IN)
TANWAR MADAN PAL (IN)
MUKHERJEE ASHIS (IN)
NARAYANAN RAMAMURTHY (IN)
RAUF ABDUL REHAMAN ABDUL (IN)
NAIK KESHAV PRABHAKAR (IN)
SONI AJAY (IN)
RAY ABHIJIT (IN)
SHIRUMALLA RAJ KUMAR (IN)
MOOKHTIAR KASIM ABBAS (IN)
Application Number:
PCT/IB2005/000803
Publication Date:
April 27, 2006
Filing Date:
March 29, 2005
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
SATTIGERI VISWAJANANI JITENDRA (IN)
ARORA SUDERSHAN K (IN)
SALMAN MOHAMMAD (US)
PALLE VENKATA P (IN)
YADAV GYAN CHAND (IN)
TANWAR MADAN PAL (IN)
MUKHERJEE ASHIS (IN)
NARAYANAN RAMAMURTHY (IN)
RAUF ABDUL REHAMAN ABDUL (IN)
NAIK KESHAV PRABHAKAR (IN)
SONI AJAY (IN)
RAY ABHIJIT (IN)
SHIRUMALLA RAJ KUMAR (IN)
MOOKHTIAR KASIM ABBAS (IN)
SATTIGERI VISWAJANANI JITENDRA (IN)
ARORA SUDERSHAN K (IN)
SALMAN MOHAMMAD (US)
PALLE VENKATA P (IN)
YADAV GYAN CHAND (IN)
TANWAR MADAN PAL (IN)
MUKHERJEE ASHIS (IN)
NARAYANAN RAMAMURTHY (IN)
RAUF ABDUL REHAMAN ABDUL (IN)
NAIK KESHAV PRABHAKAR (IN)
SONI AJAY (IN)
RAY ABHIJIT (IN)
SHIRUMALLA RAJ KUMAR (IN)
MOOKHTIAR KASIM ABBAS (IN)
International Classes:
A61K31/70; A61K31/7028; A61K31/7042; C07H3/02; C07H9/04; C07H15/00
Domestic Patent References:
| WO2000042053A1 | 2000-07-20 | |||
| WO1994028910A1 | 1994-12-22 | |||
| WO1994011381A1 | 1994-05-26 | |||
| WO1993013117A2 | 1993-07-08 | |||
| WO2004071515A1 | 2004-08-26 | |||
| WO2004099229A1 | 2004-11-18 |
Foreign References:
| US5298494A | 1994-03-29 | |||
| EP0714907A1 | 1996-06-05 | |||
| US20040192885A1 | 2004-09-30 | |||
| US5010058A | 1991-04-23 | |||
| FR2701949A1 | 1994-09-02 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 6 March 1987 (1987-03-06), KASHIWAMURA, NAOKI: "Preparation of O-(arylcarbamoyl)pentoses and -hexoses as virus inhibitors", XP002343675, retrieved from STN Database accession no. 1987:617998
CHEMICAL ABSTRACTS, vol. 110, no. 5, 30 January 1989, Columbus, Ohio, US; abstract no. 39250, MCADAM, DAVID P. ET AL: "The treatment of some carbohydrate alcohols and diols with N-dibromomethylene-N,N-dialkylammonium bromides: a synthesis of glycosyl bromides" XP002343642
GOODMAN, LEON ET AL: "Preparation of 6-acetamido-1,2,3,4-tetra-O-acetyl-6-deoxy-L- idothiopyranose", JOURNAL OF ORGANIC CHEMISTRY , 29(7), 1787-90 CODEN: JOCEAH; ISSN: 0022-3263, 1964, XP002343641
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1995, DONDONI, ALESSANDRO ET AL: "Stereoselective homologation-amination of aldehydes by addition of their nitrones to C-2 metalated thiazoles - a general entry to .alpha.-amino aldehydes and amino sugars", XP002356667, retrieved from STN Database accession no. 124:176723
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1968, PAULSEN, HANS ET AL: "Hydrazine reactions. III. Preparation of N-aminoaziridines and rearrangements to hexulose hydrazones", XP002356668, retrieved from STN Database accession no. 68:96062
TEWARI, NEETU ET AL: "Synthesis and bioevaluation of glycosyl ureas as .alpha.-glucosidase inhibitors and their effect on mycobacterium", BIOORGANIC & MEDICINAL CHEMISTRY , 11(13), 2911-2922 CODEN: BMECEP; ISSN: 0968-0896, 2003, XP002356663
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, GOUETH, PIERRE Y. ET AL: "Synthesis of ether-linked di- and trisaccharide derivatives. Part II - Functionalization and potential applications of ether-linked di- and trisaccharides containing D-glucose", XP002356669, retrieved from STN Database accession no. 122:106286
CHEMICAL ABSTRACTS, vol. 110, no. 5, 30 January 1989, Columbus, Ohio, US; abstract no. 39250, MCADAM, DAVID P. ET AL: "The treatment of some carbohydrate alcohols and diols with N-dibromomethylene-N,N-dialkylammonium bromides: a synthesis of glycosyl bromides" XP002343642
GOODMAN, LEON ET AL: "Preparation of 6-acetamido-1,2,3,4-tetra-O-acetyl-6-deoxy-L- idothiopyranose", JOURNAL OF ORGANIC CHEMISTRY , 29(7), 1787-90 CODEN: JOCEAH; ISSN: 0022-3263, 1964, XP002343641
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1995, DONDONI, ALESSANDRO ET AL: "Stereoselective homologation-amination of aldehydes by addition of their nitrones to C-2 metalated thiazoles - a general entry to .alpha.-amino aldehydes and amino sugars", XP002356667, retrieved from STN Database accession no. 124:176723
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1968, PAULSEN, HANS ET AL: "Hydrazine reactions. III. Preparation of N-aminoaziridines and rearrangements to hexulose hydrazones", XP002356668, retrieved from STN Database accession no. 68:96062
TEWARI, NEETU ET AL: "Synthesis and bioevaluation of glycosyl ureas as .alpha.-glucosidase inhibitors and their effect on mycobacterium", BIOORGANIC & MEDICINAL CHEMISTRY , 11(13), 2911-2922 CODEN: BMECEP; ISSN: 0968-0896, 2003, XP002356663
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, GOUETH, PIERRE Y. ET AL: "Synthesis of ether-linked di- and trisaccharide derivatives. Part II - Functionalization and potential applications of ether-linked di- and trisaccharides containing D-glucose", XP002356669, retrieved from STN Database accession no. 122:106286
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