Title:
MONOVALENT CD27 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2014/140374
Kind Code:
A3
Abstract:
The present invention relates to a monovalent antibody, such as a Fab fragment, which is capable of specifically binding CD27 and reducing CD27 induced signalling. The present invention also relates to a fusion protein or conjugate comprising the monovalent antibody of the invention and a half-life extending moiety. The monovalent antibody, fusion protein or conjugate of the invention may be suitable for use as a medicament, such as in the treatment of autoimmune diseases in which suppression of CD27 signaling is desirable.
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Inventors:
GRUHLER ALBRECHT (DK)
NØRBY PEDER LISBY (DK)
ZEUTHEN LOUISE HJERRILD (DK)
CHRISTENSEN LEIF (DK)
NØRBY PEDER LISBY (DK)
ZEUTHEN LOUISE HJERRILD (DK)
CHRISTENSEN LEIF (DK)
Application Number:
PCT/EP2014/055331
Publication Date:
December 04, 2014
Filing Date:
March 17, 2014
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
International Classes:
C07K16/28
Domestic Patent References:
| WO2011130434A2 | 2011-10-20 | |||
| WO2012004367A1 | 2012-01-12 | |||
| WO2013138586A1 | 2013-09-19 |
Other References:
JEVSEVAR SIMONA ET AL: "PEGylation of antibody fragments for half-life extension", METHODS IN MOLECULAR BIOLOGY, vol. 901, 1 January 2012 (2012-01-01), (CLIFTON, N.J.) UNITED STATES, pages 233 - 246, XP009169915, ISSN: 1940-6029
AGEMATSU K ET AL: "B CELL SUBPOPULATIONS SEPARATED BY CD27 AND CRUCIAL COLLABORATION OF CD27+ B CELLS AND HELPER T CELLS IN IMMUNOGLOBULIN PRODUCTION", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 27, no. 8, 1 January 1997 (1997-01-01), WILEY - V C H VERLAG GMBH & CO. KGAA, DE, pages 2073 - 2079, XP001031448, ISSN: 0014-2980, DOI: 10.1002/EJI.1830270835
KOBATA T ET AL: "CD27-CD70 interactions regulate B-cell activation by T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 92, no. 24, 21 November 1995 (1995-11-21), NATIONAL ACADEMY OF SCIENCES, US, pages 11249 - 11253, XP002582843, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.24.11249
NAKAJIMA A ET AL: "Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis", JOURNAL OF NEUROIMMUNOLOGY, vol. 109, no. 2, 22 September 2000 (2000-09-22), ELSEVIER SCIENCE PUBLISHERS BV, pages 188 - 196, XP002423716, ISSN: 0165-5728, DOI: 10.1016/S0165-5728(00)00324-6
MATTHIAS MATTER ET AL: "Elimination of chronic viral infection by blocking CD27 signaling", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 203, no. 9, 21 August 2006 (2006-08-21), ROCKEFELLER UNIVERSITY PRESS, US, pages 2145 - 2155, XP007906013, ISSN: 0022-1007, DOI: 10.1084/JEM.20060651
GREENALL SAMEER A ET AL: "Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.", PLOS ONE, vol. 7, no. 4, E34658, April 2012 (2012-04-01), pages 1 - 10, XP002697775, ISSN: 1932-6203
MAGE R G ET AL: "B cell and antibody repertoire development in rabbits: The requirement of gut-associated lymphoid tissues", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON PRESS, US, vol. 30, no. 1-2, 1 January 2006 (2006-01-01), pages 137 - 153, XP027942078, ISSN: 0145-305X, [retrieved on 20060101]
AGEMATSU K ET AL: "B CELL SUBPOPULATIONS SEPARATED BY CD27 AND CRUCIAL COLLABORATION OF CD27+ B CELLS AND HELPER T CELLS IN IMMUNOGLOBULIN PRODUCTION", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 27, no. 8, 1 January 1997 (1997-01-01), WILEY - V C H VERLAG GMBH & CO. KGAA, DE, pages 2073 - 2079, XP001031448, ISSN: 0014-2980, DOI: 10.1002/EJI.1830270835
KOBATA T ET AL: "CD27-CD70 interactions regulate B-cell activation by T cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 92, no. 24, 21 November 1995 (1995-11-21), NATIONAL ACADEMY OF SCIENCES, US, pages 11249 - 11253, XP002582843, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.24.11249
NAKAJIMA A ET AL: "Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis", JOURNAL OF NEUROIMMUNOLOGY, vol. 109, no. 2, 22 September 2000 (2000-09-22), ELSEVIER SCIENCE PUBLISHERS BV, pages 188 - 196, XP002423716, ISSN: 0165-5728, DOI: 10.1016/S0165-5728(00)00324-6
MATTHIAS MATTER ET AL: "Elimination of chronic viral infection by blocking CD27 signaling", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 203, no. 9, 21 August 2006 (2006-08-21), ROCKEFELLER UNIVERSITY PRESS, US, pages 2145 - 2155, XP007906013, ISSN: 0022-1007, DOI: 10.1084/JEM.20060651
GREENALL SAMEER A ET AL: "Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.", PLOS ONE, vol. 7, no. 4, E34658, April 2012 (2012-04-01), pages 1 - 10, XP002697775, ISSN: 1932-6203
MAGE R G ET AL: "B cell and antibody repertoire development in rabbits: The requirement of gut-associated lymphoid tissues", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON PRESS, US, vol. 30, no. 1-2, 1 January 2006 (2006-01-01), pages 137 - 153, XP027942078, ISSN: 0145-305X, [retrieved on 20060101]
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