Title:
MORANOLINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/000881
Kind Code:
A1
Abstract:
Moranoline derivatives represented by structural formula (I), wherein R1 represents lower alkyl substituted by acyl, alkoxycarbonyl, cyano, alkylcarbamoyl, nitro, acylamino, alkylthio, hydroxy or aryloxy, phenyl-lower alkyl wherein the benzene ring optionally has substituent(s) such as hydroxy, lower alkoxy, lower alkyl, halogeno, cyano, lower alkylcarbamoyl, nitro, acylamino, alkylthio or carboxy, lower alkyl substituted by a 5-membered unsaturated heterocycle optionally substituted by lower alkyl, alkenyl, arylalkenyl or higher alkyl; R2 and R3 are different from each other and each represents galactopyranosyl or fucopyranosyl substituted by hydroxysulfonyl or a metal salt thereof; and R4 represents hydroxy or acetamide. The compounds are useful in the medicinal field, for example, as an antiinflammatory agent or a preventive or remedy for ischemia and reflow disorders.
Inventors:
HASEGAWA AKIRA (JP)
OHGI TADAAKI (JP)
SETO TAKASHI (JP)
MORI KAZUYA (JP)
OHGI TADAAKI (JP)
SETO TAKASHI (JP)
MORI KAZUYA (JP)
Application Number:
PCT/JP1996/001730
Publication Date:
January 09, 1997
Filing Date:
June 21, 1996
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
HASEGAWA AKIRA (JP)
OHGI TADAAKI (JP)
SETO TAKASHI (JP)
MORI KAZUYA (JP)
HASEGAWA AKIRA (JP)
OHGI TADAAKI (JP)
SETO TAKASHI (JP)
MORI KAZUYA (JP)
International Classes:
C07H17/02; (IPC1-7): C07H17/02; A61K31/70
Domestic Patent References:
| WO1993015098A1 | 1993-08-05 | |||
| WO1994000477A1 | 1994-01-06 |
Download PDF:
Previous Patent: NOVEL ANTHRACYCLINE DERIVATIVES HAVING 4-AMINO-2,4,6-TRIDEOXY-2-FLUORO-MANNOPYRANOSYL GROUP
Next Patent: MEIOSIS REGULATING COMPOUNDS
Next Patent: MEIOSIS REGULATING COMPOUNDS