MORPHINAN DERIVATIVE AND MEDICAL USAGE THEREOF

WIPO Patent Application WO/2017/073710

A1

The purpose of the present invention is to provide a compound that is effective as a prophylactic agent or a therapeutic agent for various diseases and symptoms associated with the orexin receptor, as well as to provide a medical usage thereof. The present invention provides a morphinan derivative that is represented by general formula (I), that exhibits superior selectivity and antagonism with respect to the orexin receptor, and that exhibits superior therapeutic and prophylactic effects with respect to drug dependency, or provides a pharmacologically acceptable acid-addition salt thereof, as well as an orexin-receptor antagonist and a drug-dependency therapeutic agent or prophylactic agent, that contain the morphinan derivative or the acid-addition salt as an active ingredient.

WO/2001/029047	METHOD FOR PREPARING OXYCODONE
JP2505962	NEW VINYL CARBAMATES
JP5119925	Treatment or prevention of functional bowel disorders

NAGASE HIROSHI (JP)
YAMAMOTO NAOSHI (JP)
IRUKAYAMA YOKO (JP)
SAITOH TSUYOSHI (JP)
YANAGISAWA MASASHI (JP)
NAGUMO YASUYUKI (JP)

PCT/JP2016/081995

May 04, 2017

October 28, 2016

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TORAY INDUSTRIES (JP)

C07D489/06; A61K31/485; A61P25/00; A61P43/00; C07D489/08

WO2016152953A1	2016-09-29
WO1995003308A1	1995-02-02
WO2014152657A1	2014-09-25

BOSS, C . ET AL.: "Recent trends in orexin research-2010 to 2015", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, 2015, pages 2875 - 2887, XP029160577
See also references of EP 3369736A4

TANIGAWA AND PARTNERS, PATENT FIRM (JP)

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