Title:
MORPHINAN DERIVATIVE AND MEDICINAL USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2016/152953
Kind Code:
A1
Abstract:
The objective of the present invention is to provide an analgesic drug that is a peripherally selective opioid κ-receptor agonist and reduces side effects based on opioid μ-receptor agonists such as drug dependency and respiratory depression, and side effects based on central opioid κ-receptor agonists such as sedation and discomfort. The present invention provides a medicine that contains, as an active ingredient, a morphinan derivative represented by formula (I) or formula (II), or a pharmaceutically acceptable acid addition salt thereof.
Inventors:
TSUJI RIICHIRO (JP)
KAWAI KOJI (JP)
INADA HIDEAKI (JP)
SUGAWARA YUJI (JP)
KAWAI KOJI (JP)
INADA HIDEAKI (JP)
SUGAWARA YUJI (JP)
Application Number:
PCT/JP2016/059295
Publication Date:
September 29, 2016
Filing Date:
March 24, 2016
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07D489/08; A61K31/485; A61P25/04; A61P43/00
Domestic Patent References:
| WO1993015081A1 | 1993-08-05 |
Foreign References:
| US20090170888A1 | 2009-07-02 | |||
| JP2002308769A | 2002-10-23 |
Other References:
HORIKIRI, HIROMASA ET AL.: "Syntheses of 10-Oxo, 10a-Hydroxy, and 10b -Hydroxy Derivatives of a Potent k -Opioid Receptor Agonist, TRK-820", CHEM. PHARM. BULL., vol. 52, no. 6, 2004, pages 664 - 669, XP055315348
NEMOTO, TORU ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 7628 - 7647
SAGARA, TAKESHI ET AL.: "DESIGN AND SYNTHESIS OF 10-OXO DERIVATIVE OF NCYCLOPROPYLMETHYL(-)-613-ACETYLTHIODIHYDRONORMORPHINE,A POTENTIALLY 1c-SELECTIVEOPIOID RECEPTOR LIGAND", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 14, 1995, pages 1505 - 1508, XP055315350
NEMOTO, TORU ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 7628 - 7647
SAGARA, TAKESHI ET AL.: "DESIGN AND SYNTHESIS OF 10-OXO DERIVATIVE OF NCYCLOPROPYLMETHYL(-)-613-ACETYLTHIODIHYDRONORMORPHINE,A POTENTIALLY 1c-SELECTIVEOPIOID RECEPTOR LIGAND", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 14, 1995, pages 1505 - 1508, XP055315350
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