Title:
MORPHINAN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/136305
Kind Code:
A1
Abstract:
The present invention relates to a morphinan derivative as represented by general formula (I); a tautomer or stereoisomer of said compound; a pharmaceutically acceptable salt thereof; a solvate of the morphinan derivative or of a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof; and an analgesic, an anxiolytic agent, or the like that includes any of the above as an active ingredient. In general formula (I), R1 represents hydrogen, a C1–6 alkyl, a C6–10 aryl, or the like; R2 and R3 are the same or different and represent hydrogen, a hydroxyl, or the like; R4 and R5 represent hydrogen, a C1–6 alkyl, or the like; R6 represents hydrogen, a hydroxyl, a C1–6 alkyl, or the like; X represents O or CH2; Y represents C=O, C(=O)O, or the like; and m and n are the same or different and represent an integer from 0 to 2 (provided that both m and n are not simultaneously 0).
Inventors:
NAGASE HIROSHI (JP)
FUJII HIDEAKI (JP)
NAKATA ERIKO (JP)
WATANABE YOSHIKAZU (JP)
SAITO DAISUKE (JP)
TAKAHASHI TOSHIHIRO (JP)
FUJII HIDEAKI (JP)
NAKATA ERIKO (JP)
WATANABE YOSHIKAZU (JP)
SAITO DAISUKE (JP)
TAKAHASHI TOSHIHIRO (JP)
Application Number:
PCT/JP2013/077886
Publication Date:
September 12, 2014
Filing Date:
October 15, 2013
Export Citation:
Assignee:
KITASATO INST (JP)
NIPPON CHEMIPHAR CO (JP)
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K31/439; C07D471/08; A61P25/04; A61P25/22
Domestic Patent References:
| WO2012102360A1 | 2012-08-02 | |||
| WO1997025331A1 | 1997-07-17 | |||
| WO1996002545A1 | 1996-02-01 | |||
| WO1995031463A1 | 1995-11-23 | |||
| WO2001014382A1 | 2001-03-01 | |||
| WO2001014383A1 | 2001-03-01 | |||
| WO2008001859A1 | 2008-01-03 | |||
| WO2012102360A1 | 2012-08-02 | |||
| WO2013035833A1 | 2013-03-14 |
Other References:
J. PHARMACOL. EXP. THER., vol. 338, 2011, pages 195
TRENDS IN NEUROSCIENCES, vol. 36, 2013, pages 195
BEHAVIOURAL BRAIN RESEARCH, vol. 223, 2011, pages 271
NEUROPHARMACOLOGY, vol. 67, 2013, pages 485
CURRENT NEUROPHARMACOLOGY, vol. 10, 2012, pages 231
TETRAHEDRON, vol. 67, 2011, pages 6682
INTERNATIONAL NARCOTIC RESEARCH CONFERENCE, 14 July 2013 (2013-07-14)
OPIOID PEPTIDE SYMPOSIUM, 6 September 2013 (2013-09-06)
J. BIOL. CHEM., vol. 276, 2001, pages 15409 - 15414
TRENDS IN NEUROSCIENCES, vol. 36, 2013, pages 195
BEHAVIOURAL BRAIN RESEARCH, vol. 223, 2011, pages 271
NEUROPHARMACOLOGY, vol. 67, 2013, pages 485
CURRENT NEUROPHARMACOLOGY, vol. 10, 2012, pages 231
TETRAHEDRON, vol. 67, 2011, pages 6682
INTERNATIONAL NARCOTIC RESEARCH CONFERENCE, 14 July 2013 (2013-07-14)
OPIOID PEPTIDE SYMPOSIUM, 6 September 2013 (2013-09-06)
J. BIOL. CHEM., vol. 276, 2001, pages 15409 - 15414
Attorney, Agent or Firm:
Chigusa, Shinichi (JP)
1000 Shin-ichi Kusa (JP)
1000 Shin-ichi Kusa (JP)
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