MORPHINAN DERIVATIVE - UNIV TSUKUBA

Title:

MORPHINAN DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2016/148232

Kind Code:

A1

Abstract:

The morphinan derivatives represented by general formula (I) (wherein R1 represents hydrogen, a C1-10alkyl, a cycloalkylalkyl in which the cycloalkyl moiety has 3-6 carbon atoms and the alkylene moiety has 1-5 carbon atoms, or the like; R2 represents a heterocycle including at least one carbon atom and 1-4 heteroatoms selected from among N, O and S as constituent annular atoms, with at least one set of adjacent constituent annular atoms having a double bond, said heterocycle also including at least one oxo group as a substituent; Y is bonded to a carbon atom that is a constituent annular atom of R2; R3, R4 and R5 represent hydrogen, hydroxy or the like; R6a and R6b represent hydrogen or the like; R7 and R8 represent hydrogen or the like; R9 and R10 are the same or different, and represent hydrogen or the like; X represents O or CH2; and Y represents C(=O)), variants and stereoisomers of the derivatives, pharmaceutically acceptable salts thereof, and solvates thereof according to the present invention are used as antianxiety drugs, antidepressants and the like.

Inventors:

NAGASE HIROSHI (JP)
FUJII HIDEAKI (JP)
SAITOH AKIYOSHI (JP)
NAKATA ERIKO (JP)
HIROSE MASAAKI (JP)
OOI ISAO (JP)
HAYASHIDA KOHEI (JP)

Application Number:

PCT/JP2016/058475

Publication Date:

September 22, 2016

Filing Date:

March 17, 2016

Export Citation:

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Assignee:

UNIV TSUKUBA (JP)
SCHOOL JURIDICAL PERSON KITASATO INST (JP)
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
NIPPON CHEMIPHAR CO (JP)

International Classes:

C07D471/08; A61K31/485; A61P25/04; A61P25/22; A61P25/24; A61P43/00

Domestic Patent References:

WO2013035833A1	2013-03-14
WO2014021273A1	2014-02-06
WO2014136305A1	2014-09-12

Other References: