Title:
MORPHINANE DERIVATIVES CONTAINING A CARBOXAMIDE GROUP AS OPIOID RECEPTOR LIGANDS
Document Type and Number:
WIPO Patent Application WO/2011/119605
Kind Code:
A3
Abstract:
A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
Inventors:
WENTLAND MARK P (US)
Application Number:
PCT/US2011/029425
Publication Date:
November 17, 2011
Filing Date:
March 22, 2011
Export Citation:
Assignee:
RENSSELAER POLYTECH INST (US)
WENTLAND MARK P (US)
WENTLAND MARK P (US)
International Classes:
C07D221/28; A61K31/439; A61P1/00; A61P11/00; A61P17/00; A61P19/00; A61P25/00; C07D489/08
Domestic Patent References:
| WO2007014137A2 | 2007-02-01 |
Other References:
WENTLAND M P ET AL: "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 49, no. 18, 7 September 2006 (2006-09-07), pages 5635 - 5639, XP002550099, ISSN: 0022-2623, [retrieved on 20060810], DOI: DOI:10.1021/JM060278N
VANALSTINE ET AL: "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 23, 2 November 2007 (2007-11-02), pages 6516 - 6520, XP022325927, ISSN: 0960-894X, DOI: DOI:10.1016/J.BMCL.2007.09.082
VANALSTINE ET AL: "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 23, 2 November 2007 (2007-11-02), pages 6516 - 6520, XP022325927, ISSN: 0960-894X, DOI: DOI:10.1016/J.BMCL.2007.09.082
Attorney, Agent or Firm:
FREDERICKS, Kellie S. (5 Columbia CircleAlbany, New York, US)
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