Title:
MORPHOLINYL-UREA DERIVATIVES FOR USE OF THE TREATMENT OF INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO2003082861
Kind Code:
A3
Abstract:
Compounds of formula (I) wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5;R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl;and salts and solvates thereof;are CCR3 antagonists and are thus indicated to be useful in therapy.
Inventors:
ANCLIFF RACHAEL ANN (GB)
COOK CAROLINE MARY (GB)
ELDRED COLIN DAVID (GB)
GORE PAUL MARTIN (GB)
HARRISON LEE ANDREW (GB)
HAYES MARTIN ALISTAIR (GB)
HODGSON SIMON TEANBY (GB)
JUDD DUNCAN BRUCE (GB)
KEELING SUZANNE ELAINE (GB)
LEWELL XIAO QING (GB)
MILLS GAIL (GB)
ROBERTSON GRAEME MICHAEL (GB)
SWANSON STEPHEN (GB)
WALKER ANDREW JOHN (GB)
WILKINSON MARK (GB)
COOK CAROLINE MARY (GB)
ELDRED COLIN DAVID (GB)
GORE PAUL MARTIN (GB)
HARRISON LEE ANDREW (GB)
HAYES MARTIN ALISTAIR (GB)
HODGSON SIMON TEANBY (GB)
JUDD DUNCAN BRUCE (GB)
KEELING SUZANNE ELAINE (GB)
LEWELL XIAO QING (GB)
MILLS GAIL (GB)
ROBERTSON GRAEME MICHAEL (GB)
SWANSON STEPHEN (GB)
WALKER ANDREW JOHN (GB)
WILKINSON MARK (GB)
Application Number:
PCT/EP2003/003335
Publication Date:
March 11, 2004
Filing Date:
March 27, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
ANCLIFF RACHAEL ANN (GB)
COOK CAROLINE MARY (GB)
ELDRED COLIN DAVID (GB)
GORE PAUL MARTIN (GB)
HARRISON LEE ANDREW (GB)
HAYES MARTIN ALISTAIR (GB)
HODGSON SIMON TEANBY (GB)
JUDD DUNCAN BRUCE (GB)
KEELING SUZANNE ELAINE (GB)
LEWELL XIAO QING (GB)
MILLS GAIL (GB)
ROBERTSON GRAEME MICHAEL (GB)
SWANSON STEPHEN (GB)
WALKER ANDREW JOHN (GB)
WILKINSON MARK (GB)
ANCLIFF RACHAEL ANN (GB)
COOK CAROLINE MARY (GB)
ELDRED COLIN DAVID (GB)
GORE PAUL MARTIN (GB)
HARRISON LEE ANDREW (GB)
HAYES MARTIN ALISTAIR (GB)
HODGSON SIMON TEANBY (GB)
JUDD DUNCAN BRUCE (GB)
KEELING SUZANNE ELAINE (GB)
LEWELL XIAO QING (GB)
MILLS GAIL (GB)
ROBERTSON GRAEME MICHAEL (GB)
SWANSON STEPHEN (GB)
WALKER ANDREW JOHN (GB)
WILKINSON MARK (GB)
International Classes:
C07D413/12; A61K31/5377; A61P11/02; A61P11/06; A61P29/00; A61P43/00; C07D231/12; C07D253/06; C07D257/04; C07D271/06; C07D307/34; C07D333/38; C07D413/14; C07D417/12; (IPC1-7): C07D413/12; C07D271/06; C07D307/34; C07D231/12; C07D257/04; C07D253/06; C07D333/38; A61P29/00
Domestic Patent References:
| WO2002026723A1 | 2002-04-04 |
Foreign References:
| US5919776A | 1999-07-06 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 016, no. 544 (C - 1004) 13 November 1992 (1992-11-13)
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