MORPHOLINYLMETHYLUREAS CCR-3 RECEPTOR ANTAGONIST

WIPO Patent Application WO2003099798

A8

Compounds of formula (I): wherein:R<1> represents C3-8 cycloalkyl-Y<1>-, aryl-Y<1>-, heteroaryl-Y<1>-, aryl- G-Y<1>-, heteroaryl-G-Y<1>-, C1-6 alkyl-G-Y<1>-, J<1>-Y<1>-, R<22>R<23>N-Y<1>-, R<22>R<23>N-CO-Y<1>- or R<24>-CONR<22>-Y<1>-; Q represents -(CR<19>R<20>)(CR<19a>R<20a>)t-, wherein t represents an integer from 0 to 3;R<2> and R<3> independently represent hydrogen or C1-6 alkyl;X represents ethylene or a group of formula CRR wherein R and R independently represent hydrogen or C1-4 alkyl or R and R may together with the carbon atom to which they are attached form a C3-8 cycloalkyl group; R<4> and R<5> independently represent hydrogen or C1-4 alkyl; Z represents a bond, CO, SO2, CR<10>R<7>(CH2)n, (CH2)nCR<10>R<7>, CR<10>R<7>(CH2)nO, CR<10>R<7>(CH2)nS, CR<10>R<7>(CH2)nCO, COCR<10>R<7>(CH2)n or SO2CR<10>R<7>(CH2)n; R<6> represents aryl, heteroaryl or aryl-C2-6 alkenyl-; R<7> represents hydrogen, C1-4 alkyl, CONR<8>R<9> or COOC1-6 alkyl;a and b represent 1 or 2, such that a+b represents 2 or 3;G represents -S-, -SO2-, -SO2NR<21>, -NR<21>SO2 or -NR<21>-; n represents an integer from 0 to 4; J<1> independently represents a moiety of formula (K): wherein X<1> represents oxygen, NR<11> or sulphur, X<2> represents CH2, oxygen, NR<12> or sulphur, m<1> represents an integer from 1 to 3, m<2> represents an integer from 1 to 3, provided that m<1>+m<2> is in the range from 3 to 5, also provided that when both X<1> and X<2> represent oxygen, NR<11>, NR<12> or sulphur, m<1> and m<2> must both not equal less than 2, wherein K is optionally substituted by one or more (eg. 1 or 2) -Y<3>-aryl, -Y<3>-heteroaryl, -Y<3>-CO-aryl, -Y<3>-CO-heteroaryl, -C1-6 alkyl, -Y<3>-COOC1-6 alkyl, -Y<3>-COC1-6 alkyl, -Y<3>-W, -Y<3>-CO-W, -Y<3>-NR<15>R<16>, -Y<3>-CONR<15>R<16>, hydroxy, oxo, -Y<3>-SO2NR<15>R<16>, -Y<3>-SO2C1-6 alkyl, -Y<3>-SO2aryl, -Y<3>-SO2heteroaryl, -Y<3>-NR<13>C1-6 alkyl, -Y<3>-NR<13>SO2C1-6 alkyl, -Y<3>-NR<13>CONR<15>R<16>, -Y<3>-NR<13>COOR<14> or -Y<3>-OCONR<15>R<16> groups, and is optionally fused to a monocyclic aryl or heteroaryl ring;R<8>, R<9>, R<10>, R<11>, R<12>, R<13> and R<14