Title:
MOTIF-GRAFTED HYBRID POLYPEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003085086
Kind Code:
A3
Abstract:
Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious from of a prion (PrPSc) is provided.
Inventors:
BURTON DENNIS R (US)
WILLIAMSON R ANTHONY (US)
MORONCINI GIANLUCA (US)
WILLIAMSON R ANTHONY (US)
MORONCINI GIANLUCA (US)
Application Number:
PCT/US2003/010856
Publication Date:
July 27, 2006
Filing Date:
April 08, 2003
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
BURTON DENNIS R (US)
WILLIAMSON R ANTHONY (US)
MORONCINI GIANLUCA (US)
BURTON DENNIS R (US)
WILLIAMSON R ANTHONY (US)
MORONCINI GIANLUCA (US)
International Classes:
C07K1/00; A61K38/00; G01N33/53; C07K2/00; C07K4/00; C07K14/00; C07K14/47; C07K16/00; C07K16/10; C07K16/18; C07K16/42; C07K16/46; C07K17/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/62; C12Q1/02; G01N33/68
Foreign References:
EP0613007A2 | 1994-08-31 | |||
US6214565B1 | 2001-04-10 | |||
US6172043B1 | 2001-01-09 | |||
US5773572A | 1998-06-30 |
Other References:
See also references of EP 1572937A4
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