Title:
MOTOR PROTEINS AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO2002079479
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators
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Inventors:
BERAUD CHRISTOPHE (US)
FREEDMAN RICHARD (US)
FREEDMAN RICHARD (US)
Application Number:
PCT/US2001/043596
Publication Date:
October 23, 2003
Filing Date:
November 16, 2001
Export Citation:
Assignee:
CYTOKINETICS INC (US)
BERAUD CHRISTOPHE (US)
FREEDMAN RICHARD (US)
BERAUD CHRISTOPHE (US)
FREEDMAN RICHARD (US)
International Classes:
C07H21/04; C12N9/00; C12N9/14; C12N15/55; C12Q1/68; (IPC1-7): C12N15/55; C12N9/14; C12N5/10; G01N33/68
Other References:
HANLON D W ET AL: "Characterization of KIFC2, a neuronal kinesin superfamily member in mouse.", NEURON. UNITED STATES MAR 1997, vol. 18, no. 3, O08613, March 1997 (1997-03-01), pages 439 - 451, XP001159168, ISSN: 0896-6273, Retrieved from the Internet
SAITO N ET AL: "KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.", NEURON. UNITED STATES MAR 1997, vol. 18, no. 3, March 1997 (1997-03-01), pages 425 - 438, XP001161244, ISSN: 0896-6273
HIROKAWA N: "The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors.", CURRENT OPINION IN NEUROBIOLOGY. ENGLAND OCT 1997, vol. 7, no. 5, October 1997 (1997-10-01), pages 605 - 614, XP001159167, ISSN: 0959-4388
VOLORIO S ET AL: "SEQUENCING ANALYSIS OF FORTY-EIGHT HUMAN IMAGE CDNA CLONES SIMILAR TO DROSOPHILA MUTANT PROTEIN", DNA SEQUENCE, NEW YORK, NY, US, vol. 9, no. 5/6, U69186, 1998, pages 307 - 315, XP000986990, ISSN: 1042-5179, Retrieved from the Internet
DATABASE TREMBL [online] 1 December 2001 (2001-12-01), STARUSBERG ET AL.: "Similar to kinesin family member C2", XP002249291, retrieved from EBI Database accession no. Q96AC6
SAITO N ET AL: "KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.", NEURON. UNITED STATES MAR 1997, vol. 18, no. 3, March 1997 (1997-03-01), pages 425 - 438, XP001161244, ISSN: 0896-6273
HIROKAWA N: "The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors.", CURRENT OPINION IN NEUROBIOLOGY. ENGLAND OCT 1997, vol. 7, no. 5, October 1997 (1997-10-01), pages 605 - 614, XP001159167, ISSN: 0959-4388
VOLORIO S ET AL: "SEQUENCING ANALYSIS OF FORTY-EIGHT HUMAN IMAGE CDNA CLONES SIMILAR TO DROSOPHILA MUTANT PROTEIN", DNA SEQUENCE, NEW YORK, NY, US, vol. 9, no. 5/6, U69186, 1998, pages 307 - 315, XP000986990, ISSN: 1042-5179, Retrieved from the Internet
DATABASE TREMBL [online] 1 December 2001 (2001-12-01), STARUSBERG ET AL.: "Similar to kinesin family member C2", XP002249291, retrieved from EBI Database accession no. Q96AC6
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