Title:
MRNA, PROTEIN AND VACCINE AGAINST SARS-COV-2 INFECTION
Document Type and Number:
WIPO Patent Application WO/2023/051701
Kind Code:
A1
Abstract:
An mRNA against SARS-CoV-2 infection. The template DNA of the mRNA comprises an antigen encoding region. The antigen encoding region encodes a signal peptide-free S protein of a SARS-CoV-2 Delta mutant, wherein the S protein of the Delta mutant has at least one mutation of K986P and V987P mutations; the antigen encoding region encodes an NTD_RBD domain of a SARS-CoV-2 Delta mutant, wherein the NTD_RBD domain of the Delta mutant has a C538S mutation; the antigen encoding region encodes at least one of a RBD domain of a SARS-CoV-2 Delta mutant and an NTD_RBD domain of a SARS-CoV-2 Gamma mutant, wherein the RBD domain of the SARS-CoV-2 Delta mutant has a C538S mutation, and the NTD_RBD domain of the SARS-CoV-2 Gamma mutant has a D80A mutation, an R246I mutation and a C538S mutation, and has Δ242-244 of a Beta mutant added thereto; or the antigen encoding region encodes an RBD domain of the S protein of a SARS-CoV-2 Delta mutant, an RBD domain of the S protein of a SARS-CoV-2 Beta mutant, an RBD domain of the S protein of a SARS-CoV-2 Gamma mutant and an RBD domain of the S protein of wild-type SARS-CoV-2.
Inventors:
WEI XIAWEI (CN)
SONG XIANGRONG (CN)
WEI YUQUAN (CN)
SONG XIANGRONG (CN)
WEI YUQUAN (CN)
Application Number:
PCT/CN2022/122626
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
WESTGENE BIOPHARMA CO LTD (CN)
International Classes:
A61K39/215; A61P31/14; C07K14/165; C07K19/00; C12N5/10; C12N15/62; C12N15/85
Foreign References:
| CN112480217A | 2021-03-12 | |||
| CN112386684A | 2021-02-23 | |||
| CN113292640A | 2021-08-24 | |||
| CN113150085A | 2021-07-23 | |||
| CN113150084A | 2021-07-23 |
Other References:
VOGEL ANNETTE B.; KANEVSKY ISIS; CHE YE; SWANSON KENA A.; MUIK ALEXANDER; VORMEHR MATHIAS; KRANZ LENA M.; WALZER KERSTIN C.; HEIN : "BNT162b vaccines protect rhesus macaques from SARS-CoV-2", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 592, no. 7853, 1 February 2021 (2021-02-01), London, pages 283 - 289, XP037417629, ISSN: 0028-0836, DOI: 10.1038/s41586-021-03275-y
YANG, JINGYUN ET AL.: "A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity", NATURE, vol. 586, 29 July 2020 (2020-07-29), XP037277111, DOI: 10.1038/s41586-020-2599-8
YE FEI, LIN XI, CHEN ZIMIN, YANG FANLI, LIN SHENG, YANG JING, CHEN HUA, SUN HONGLU, WANG LINGLING, WEN AO, ZHANG XINDAN, DAI YUSHA: "S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 6, no. 1, 16 September 2021 (2021-09-16), XP055866816, DOI: 10.1038/s41392-021-00756-4
YANG, JINGYUN ET AL.: "A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity", NATURE, vol. 586, 29 July 2020 (2020-07-29), XP037277111, DOI: 10.1038/s41586-020-2599-8
YE FEI, LIN XI, CHEN ZIMIN, YANG FANLI, LIN SHENG, YANG JING, CHEN HUA, SUN HONGLU, WANG LINGLING, WEN AO, ZHANG XINDAN, DAI YUSHA: "S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 6, no. 1, 16 September 2021 (2021-09-16), XP055866816, DOI: 10.1038/s41392-021-00756-4
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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