Title:
MS-444 DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1998/032750
Kind Code:
A1
Abstract:
Novel MS-444 derivatives having excellent immunosuppressive and anti-itching effects and represented by general formula (I) wherein R?1� and R?2� are the same or different from each other and each represents hydrogen or lower alkyl; V?1� represents hydroxy, lower alkoxy, etc.; V?2� represents oxygen together with V?1� or a bond together with W?1�; W?1� represents hydrogen or a bond together with V?2� or X?2�, etc.; X?1� represents lower alkyl or oxygen together with X?2�; X?2� represents hydrogen or oxygen together with X?1�, etc.; Y represents hydrogen or a bond together with W?2�; W?2� represents hydrogen or a bond together with Y, etc.; and Z represents hydrogen or a bond together with W?2�, provided that the case where R?1� and R?2� are each hydrogen, X?1� is methyl, V?1� and V?2� together form oxygen, a pair of W?1� and X?2� and a pair of Y and W?2� represent each a bond, and Z is hydrogen is excluded.
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Inventors:
TATSUTA KUNIAKI (JP)
NAKANISHI SATOSHI (JP)
TAKAHASHI ISAMI (JP)
NAKANISHI SATOSHI (JP)
TAKAHASHI ISAMI (JP)
Application Number:
PCT/JP1998/000265
Publication Date:
July 30, 1998
Filing Date:
January 23, 1998
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
TATSUTA KUNIAKI (JP)
NAKANISHI SATOSHI (JP)
TAKAHASHI ISAMI (JP)
TATSUTA KUNIAKI (JP)
NAKANISHI SATOSHI (JP)
TAKAHASHI ISAMI (JP)
International Classes:
C07D307/92; (IPC1-7): C07D307/92; A61K31/34
Domestic Patent References:
| WO1993009109A1 | 1993-05-13 |
Other References:
"TOTAL SYNTHESIS OF MS-444, A MYOSIN LIGHT CHAIN KINASE INHIBITOR.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 50., no. 03., 1 March 1997 (1997-03-01), GB, pages 289/290., XP002914044, ISSN: 0021-8820
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