MUCISPIRILLUM COMPOSITIONS AND CANCER TREATMENT METHODS THEREOF

Title:

MUCISPIRILLUM COMPOSITIONS AND CANCER TREATMENT METHODS THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/015955

Kind Code:

A3

Abstract:

The technology described herein is directed to compositions comprising Mucispirillum (e.g., M. schaedleri). Also described herein are methods of treating cancer using Mucispirillum compositions; a diet high in sulfur amino acids (SAA) or a supplement comprising SAAs; and/or XCL1 polypeptides (or XCR1 agonists). Also described herein are cancer treatment stratification methods related to detection of the level of M. schaedleri, XCL1 polypeptide, NKTs, and/or CD103+ cDC1s, and alteration or stratification of treatment accordingly.

Inventors:

GARRETT WENDY SARAH (US)
LOBEL LIOR (US)

Application Number:

PCT/US2023/070197

Publication Date:

April 04, 2024

Filing Date:

July 14, 2023

Export Citation:

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Assignee:

HARVARD COLLEGE (US)

International Classes:

G01N33/574; A23L33/135; A61K9/19; A61K9/48; A61K31/445; A61P35/00; C12N1/20; A61P31/00

Attorney, Agent or Firm:

YOUNG, Alissa R. et al. (US)

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