MUCOACTIVE AGENTS FOR TREATING A PULMONARY DISEASE

Title:

MUCOACTIVE AGENTS FOR TREATING A PULMONARY DISEASE

Document Type and Number:

WIPO Patent Application WO2005025540

Kind Code:

A3

Abstract:

The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to pharmaceutical compositions for administration by pulmonary inhalation. It also relates to methods for producing particles suitable for pulmonary inhalation, such as spray drying or jet milling.

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Inventors:

MORTON DAVID (GB)
GANDERTON DAVID (GB)
STANIFORTH JOHN (GB)
KAMLAG YORICK (GB)

Application Number:

PCT/GB2004/003932

Publication Date:

June 16, 2005

Filing Date:

September 15, 2004

Export Citation:

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Assignee:

VECTURA LTD (GB)
MORTON DAVID (GB)
GANDERTON DAVID (GB)
STANIFORTH JOHN (GB)
KAMLAG YORICK (GB)

International Classes:

A61K31/727; A61P11/12; (IPC1-7): A61K9/12; A61K9/14; A61K31/198; A61K31/727; A61P11/12

Domestic Patent References:

WO2001015672A2	2001-03-08
WO2003068188A1	2003-08-21
WO2003068187A1	2003-08-21
WO2003068254A1	2003-08-21
WO1999006025A1	1999-02-11
WO1994002107A2	1994-02-03
WO1998004133A1	1998-02-05

Other References:

LEE M M ET AL: "Effect of low molecular weight (MW) heparin on the elasticity of dog mucus", CLINICAL AND INVESTIGATIVE MEDICINE, no. SUPPL., 1998, & ANNUAL MEETING OF THE CANADIAN SOCIETY FOR CLINICAL INVESTIGATION, THE ROYAL COLLEGE OF PHYSICIANS A; TORONTO, ONTARIO, CANADA; SEPTEMBER 24-27, 1998, pages S102, XP009039322, ISSN: 0147-958X
LEE MM, H. GARRETT, E. SUDO, W. A. BOYD, AND M. KING: "Mucociliary clearance increase due to low molecular weight heparin", PEDIATR. PULMONOL, no. s17, 1998, pages 386, XP000903996

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