Title:
MUCOADHESIVE PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/116152
Kind Code:
A1
Abstract:
The present invention relates to a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. When the composition of the present invention is used as an oral preparation, the retention time of the preparation in the gastrointestinal tract is extended by the mucoadhesive and swelling properties thereof, such that the composition is useful in improving the absorption of oral sustained release preparations, retentive preparations of active ingredients with limited absorption sites, and active ingredients with varying solubilities according to pH.
Inventors:
PARK SANG YEOB (KR)
YOON JONG WON (KR)
YOON JONG WON (KR)
Application Number:
PCT/KR2016/015445
Publication Date:
July 06, 2017
Filing Date:
December 29, 2016
Export Citation:
Assignee:
SAMYANG BIOPHARMACEUTICALS (KR)
International Classes:
A61K47/36; A61K9/00; A61K47/32; A61K47/34; A61K47/38; A61K47/42
Other References:
SABERI, J. ET AL.: "Chitosan-poly Acrylic Acid Hybrid Nano Particle as a Novel Bioadhesive.", PROCEEDINGS OF 5TH INTERNATIONAL CONGRESS ON NANOSCIENCE & NANOTECHNOLOGY, 2014, Tehran, Iran, pages 1 - 3, XP055558448
TORRADO, S. ET AL.: "Chitosan-poly(aerylic) Acid Polyionic Complex: In Vivo Study to Demonstrate Prolonged Gastric Retention.", BIOMATERIALS, vol. 25, no. 5, 2004, pages 917 - 923, XP 004472550
SAJEESH, S. ET AL.: "Novel pH Responsive Polymethacrylic Acid-chitosan-polyethylene Glycol Nanoparticles for Oral Peptide Delivery.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, vol. 76B, no. 2, 2006, pages 298 - 305, XP 055150882
SAJEESH, S. ET AL.: "Mucoadhesive Hydrogel Microparticles Based on Poly(methacrylic Acid-vinyl Pyrrolidone)-chitosan for Oral Drug Delivery.", DRUG DELIVERY, vol. 18, no. 4, 2011, pages 227 - 235, XP 055397265
GUJARATHI, N. A. ET AL.: "pH Sensitive Polyelectrolyte Complex of O-carboxymethyl Chitosan and Poly(Acrylic Acid) Cross-linked with Calcium for Sustained Delivery of Acid Susceptible Drugs.", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 436, no. 1-2, 2012, pages 418 - 425, XP 055397272
See also references of EP 3398615A4
TORRADO, S. ET AL.: "Chitosan-poly(aerylic) Acid Polyionic Complex: In Vivo Study to Demonstrate Prolonged Gastric Retention.", BIOMATERIALS, vol. 25, no. 5, 2004, pages 917 - 923, XP 004472550
SAJEESH, S. ET AL.: "Novel pH Responsive Polymethacrylic Acid-chitosan-polyethylene Glycol Nanoparticles for Oral Peptide Delivery.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, vol. 76B, no. 2, 2006, pages 298 - 305, XP 055150882
SAJEESH, S. ET AL.: "Mucoadhesive Hydrogel Microparticles Based on Poly(methacrylic Acid-vinyl Pyrrolidone)-chitosan for Oral Drug Delivery.", DRUG DELIVERY, vol. 18, no. 4, 2011, pages 227 - 235, XP 055397265
GUJARATHI, N. A. ET AL.: "pH Sensitive Polyelectrolyte Complex of O-carboxymethyl Chitosan and Poly(Acrylic Acid) Cross-linked with Calcium for Sustained Delivery of Acid Susceptible Drugs.", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 436, no. 1-2, 2012, pages 418 - 425, XP 055397272
See also references of EP 3398615A4
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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