Title:
MUCOSAL IMMUNITY-STIMULATING AGENT, AND ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION
Document Type and Number:
WIPO Patent Application WO/2013/191225
Kind Code:
A1
Abstract:
A mucosal immunity-stimulating agent comprises a Kampo medicine having a revitalizing activity and a mucosal adjuvant. An oral pharmaceutical composition for treating HPV infection comprises at least E7 polypeptide of HPV and a Kampo medicine having a revitalizing activity.
Inventors:
KAWANA KEI (JP)
TAGUCHI AYUMI (JP)
TAGUCHI AYUMI (JP)
Application Number:
PCT/JP2013/066893
Publication Date:
December 27, 2013
Filing Date:
June 19, 2013
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K35/74; A61K36/25; A61K38/00; A61K39/12; A61K39/39; A61P35/00; A61P37/04; A61K39/00; C07K14/01; C12N1/20; C12N1/21; C12N15/09
Domestic Patent References:
| WO2003078455A2 | 2003-09-25 | |||
| WO2000045841A2 | 2000-08-10 | |||
| WO2007018152A1 | 2007-02-15 | |||
| WO2004028561A1 | 2004-04-08 | |||
| WO1998042375A1 | 1998-10-01 | |||
| WO2000037609A2 | 2000-06-29 | |||
| WO2006100108A1 | 2006-09-28 | |||
| WO1996006627A1 | 1996-03-07 | |||
| WO1999026654A1 | 1999-06-03 |
Foreign References:
| JP2001523729A | 2001-11-27 | |||
| JP2005500336A | 2005-01-06 | |||
| JP2006070217A | 2006-03-16 | |||
| JP2005097267A | 2005-04-14 |
Other References:
MATSUMOTO T ET AL.: "Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles.", EVID BASED COMPLEMENT ALTERNAT MED., vol. 7, no. 1, 29 October 2007 (2007-10-29), pages 69 - 77, XP008175992
KOICHIRO SAITO: "Koto Nyutoshusho", JOHNS, vol. 27, no. 9, 1 September 2011 (2011-09-01), pages 1460 - 1462, XP008175909
CYONG J ET AL.: "Immunomodulatory action of Kampo tonics and its potential mode of action in aged mice, Journal of traditional medicines", vol. 15, no. 5, 27 February 1999 (1999-02-27), pages 280 - 281, XP008175991
NORITO TAKEMOTO ET AL.: "Effect of TJ-48 on murine cellular immunity", JAPANESE JOURNAL OF INFLAMMATION, vol. 9, no. 1, 1989, pages 49 - 52, XP003034247
MATSUMOTO T ET AL.: "Orally administered Kampo (Japanese herbal) medicine, ''Juzen-Taiho- To'' modulates cytokine secretion in gut associated lymphoreticular tissues in mice.", PHYTOMEDICINE., vol. 6, no. 6, January 2000 (2000-01-01), pages 425 - 430, XP055182238
ADACHI K ET AL.: "Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7.", VACCINE., vol. 28, no. 16, 17 February 2010 (2010-02-17), pages 2810 - 2817, XP055182241
TAGUCHI A ET AL.: "Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner.", VACCINE., vol. 30, no. 36, 21 June 2012 (2012-06-21), pages 5368 - 5372, XP028428427
R. HOPFL ET AL., LANCET, vol. 356, 2000, pages 1985 - 1986
C. L. TRIMBLE; I. H. FRAZER, LANCET ONCOL., vol. 10, 2009, pages 975 - 980
H. POO ET AL., INT J. CANCER, vol. 119, 2006, pages 1702 - 1709
N. G. CORTESS-PEREZ ET AL., VACCINE, vol. 25, 2007, pages 6581 - 6588
K. ADACHI ET AL., VACCINE, vol. 28, 2010, pages 2810 - 2817
H. KIYOHARA ET AL., EVID. BASED COMPLEMENT. ALTERNAT. MED., vol. 3, 2006, pages 459 - 467
A. DALPKE ET AL., IMMUNOLOGY, vol. 204, 2001, pages 667 - 676
D. MIZUNO ET AL., VACCINE, vol. 29, 2011, pages 5368 - 5378
H. KAYAMURO ET AL., BIOMATERIALS, vol. 30, 2009, pages 5869 - 5876
H. FUJITA ET AL., J. IMMUNOL., vol. 183, 2009, pages 254 - 260
Y. MORISHIMA ET AL., EUR. J. IMMUNOL., vol. 35, 2005, pages 2803 - 2814
POO H. ET AL., INT. J. IMMUNOL., vol. 119, 2006, pages 1702 - 1709
KOICHIRO SAITO: "Koto Nyutoshusho", JOHNS, vol. 27, no. 9, 1 September 2011 (2011-09-01), pages 1460 - 1462, XP008175909
CYONG J ET AL.: "Immunomodulatory action of Kampo tonics and its potential mode of action in aged mice, Journal of traditional medicines", vol. 15, no. 5, 27 February 1999 (1999-02-27), pages 280 - 281, XP008175991
NORITO TAKEMOTO ET AL.: "Effect of TJ-48 on murine cellular immunity", JAPANESE JOURNAL OF INFLAMMATION, vol. 9, no. 1, 1989, pages 49 - 52, XP003034247
MATSUMOTO T ET AL.: "Orally administered Kampo (Japanese herbal) medicine, ''Juzen-Taiho- To'' modulates cytokine secretion in gut associated lymphoreticular tissues in mice.", PHYTOMEDICINE., vol. 6, no. 6, January 2000 (2000-01-01), pages 425 - 430, XP055182238
ADACHI K ET AL.: "Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7.", VACCINE., vol. 28, no. 16, 17 February 2010 (2010-02-17), pages 2810 - 2817, XP055182241
TAGUCHI A ET AL.: "Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner.", VACCINE., vol. 30, no. 36, 21 June 2012 (2012-06-21), pages 5368 - 5372, XP028428427
R. HOPFL ET AL., LANCET, vol. 356, 2000, pages 1985 - 1986
C. L. TRIMBLE; I. H. FRAZER, LANCET ONCOL., vol. 10, 2009, pages 975 - 980
H. POO ET AL., INT J. CANCER, vol. 119, 2006, pages 1702 - 1709
N. G. CORTESS-PEREZ ET AL., VACCINE, vol. 25, 2007, pages 6581 - 6588
K. ADACHI ET AL., VACCINE, vol. 28, 2010, pages 2810 - 2817
H. KIYOHARA ET AL., EVID. BASED COMPLEMENT. ALTERNAT. MED., vol. 3, 2006, pages 459 - 467
A. DALPKE ET AL., IMMUNOLOGY, vol. 204, 2001, pages 667 - 676
D. MIZUNO ET AL., VACCINE, vol. 29, 2011, pages 5368 - 5378
H. KAYAMURO ET AL., BIOMATERIALS, vol. 30, 2009, pages 5869 - 5876
H. FUJITA ET AL., J. IMMUNOL., vol. 183, 2009, pages 254 - 260
Y. MORISHIMA ET AL., EUR. J. IMMUNOL., vol. 35, 2005, pages 2803 - 2814
POO H. ET AL., INT. J. IMMUNOL., vol. 119, 2006, pages 1702 - 1709
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
Koichi Hirota (JP)
Koichi Hirota (JP)
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