MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE - BRIGHTGENE BIO-MEDICAL TECH CO LTD

Title:

MULTI-ARM POLYMERIC TARGETING ANTI-CANCER CONJUGATE

Document Type and Number:

WIPO Patent Application WO/2017/198124

Kind Code:

A1

Abstract:

Disclosed is a multi-arm targeting drug coupling agent modified by a water-soluble polymer; the drug coupling agent has the structural formula of (III). In formula (III), R is an organic center, POLY is a polymer, L is a polyvalent linker, T is a targeting molecule, D is a camptothecin drug, and q is any integer between 3 and 8. The drug conjugate can improve the poor water solubility, high toxicity and low bioavailability of camptothecin drugs.

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Inventors:

YUAN JIANDONG (CN)
HUANG YANGQING (CN)
SONG YUNSONG (CN)
YUAN FANG (CN)

Application Number:

PCT/CN2017/084328

Publication Date:

November 23, 2017

Filing Date:

May 15, 2017

Export Citation:

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Assignee:

BRIGHTGENE BIO-MEDICAL TECH CO LTD (CN)

International Classes:

A61K31/4745; A61P35/00; C08G65/34; C08G65/48

Domestic Patent References:

WO2005028539A2	2005-03-31
WO2011063156A2	2011-05-26
WO2015187540A1	2015-12-10
WO2005028539A2	2005-03-31
WO2010019233A1	2010-02-18
WO2011063156A2	2011-05-26
WO2011063158A1	2011-05-26
WO2009126349A2	2009-10-15

Foreign References:

CN105396141A	2016-03-16
CN104784699A	2015-07-22
US5281698A	1994-01-25
US5468478A	1995-11-21
US5672662A	1997-09-30
US5650234A	1997-07-22

Other References:

"Technical guidelines for non-clinical research on cytotoxic antitumor drugs", CHINESE CFDA
"Technical guidelines for non-clinical research on cytotoxic antitumor drugs", November 2006, CHINESE CFDA
"Technical guidelines for non-clinical research on cytotoxic antitumor drugs", CHINESE SFDA
"Technical guidelines for non-clinical research on cytotoxic antitumor drugs", November 2016, CHINESE SFDA
See also references of EP 3459546A4

Attorney, Agent or Firm:

LINDA LIU & PARTNERS (CN)

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