Title:
MULTI-ARMED MYXOMA VIRUS
Document Type and Number:
WIPO Patent Application WO/2022/187148
Kind Code:
A3
Abstract:
Disclosed herein, in certain embodiments, are recombinant myxoma viruses (MYXVs) and nucleic acid constructs encoding the recombinant oncolytic virus genomes and parts thereof. In some embodiments, the nucleic acid constructs include at least a portion of myxoma virus (MYXV) genome and a transgene (e.g., IL-12) driven by poxvirus PI 1 late promoter. The transgene is inserted at the MYXV genome to reduce or disrupt the expression of Ml 53 gene of the MYXV genome.
Inventors:
SHARP LESLIE LYNNE (US)
FRANCO ACHURY LINA (US)
TORRES-DOMINGUEZ LINO (US)
FRANCO ACHURY LINA (US)
TORRES-DOMINGUEZ LINO (US)
Application Number:
PCT/US2022/018164
Publication Date:
November 24, 2022
Filing Date:
February 28, 2022
Export Citation:
Assignee:
ONCOMYX THERAPEUTICS INC (US)
International Classes:
A61K35/768; A61K39/275; A61P35/00; C07K14/54; C12N15/86
Domestic Patent References:
| WO2020037206A1 | 2020-02-20 |
Foreign References:
| US20160130317A1 | 2016-05-12 | |||
| US20180080048A1 | 2018-03-22 | |||
| US20170080106A1 | 2017-03-23 | |||
| US20190076460A1 | 2019-03-14 | |||
| US20210061864A1 | 2021-03-04 |
Other References:
LIU JIA, WENNIER SONIA, REINHARD MARY, ROY EDWARD, MACNEILL AMY, MCFADDEN GRANT: "Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits", J. VIROL, vol. 83, no. 11, June 2009 (2009-06-01), pages 5933 - 5938, XP093011076
Attorney, Agent or Firm:
WILLIAMSON, David R. (US)
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