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Title:
MULTI-ARMED POLYETHYLENE GLYCOL AND ACTIVE DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/157188
Kind Code:
A1
Abstract:
Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or different -(OCH2CH2)m-, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.

Inventors:
WEI ZHEN (CN)
LIN MEINA (CN)
ZHU ZHENGANG (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2017/075599
Publication Date:
September 21, 2017
Filing Date:
March 03, 2017
Export Citation:
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Assignee:
JENKEM TECH CO LTD (BEIJING) (CN)
International Classes:
C08G65/28; A61K9/06; A61K31/4745; A61K47/60; C07C41/03; C07C43/13
Foreign References:
CN104877127A2015-09-02
JP2017122016A2017-07-13
GB1285373A1972-08-16
JP2003246835A2003-09-05
CN102108119A2011-06-29
CN101724144A2010-06-09
CN104497303A2015-04-08
Attorney, Agent or Firm:
BRIGHTHEAD INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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