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Title:
MULTI-DROP TREE BRANCHING POLYETHYLENE GLYCOL-OLIGOPEPTIDES AND ACTIVE DERIVATES AND PHARMACEUTICAL COMPOUNDS THERE OF
Document Type and Number:
WIPO Patent Application WO/2005/121181
Kind Code:
A1
Abstract:
Multi-drop tree branching polyethylene glycol-oligopeptides and active derivates of formula II, in which, R1 is a center molecule, containing multiple active groups, on these groups linear PEG is derivated and therefor forming finally multi-drop tree branching polyethylene glycol; i is an interger of 3-30, presenting multi-drop tree branches numbers. The polymer is non-poisonous and can carry multi pharmaceutic molecules, having high solubility and allowing controlled release, particularly the polymer can increase effects of antitumer medicines, such as taxol and campothecine. The multi-drop tree branching polyethylene glycol-oligopeptides of the invention can form gel with other molecules and can be used in the biopharmaceutical usages.

Inventors:
JI SHISHAN (CN)
ZHU DEQUAN (CN)
Application Number:
PCT/CN2005/000834
Publication Date:
December 22, 2005
Filing Date:
June 10, 2005
Export Citation:
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Assignee:
BEIJING JENKEM TECHNOLOGY CO L (CN)
JI SHISHAN (CN)
ZHU DEQUAN (CN)
International Classes:
A61K47/48; C07K7/02; C07K17/08; (IPC1-7): C07K17/08
Domestic Patent References:
WO2003074586A12003-09-12
Foreign References:
CN1384512A2002-12-11
CN1461762A2003-12-17
Attorney, Agent or Firm:
LEADER PATENT & TRADEMARK FIRM (TOPBOX Building No. 69 Beichen West Roa, Chaoyang District Beijing 9, CN)
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