Title:
MULTI-DRUG COMBINED REHABILITATION ELECTUARY FOR TYPE 2 DIABETES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/219033
Kind Code:
A1
Abstract:
Disclosed are a multi-drug combined rehabilitation electuary for type 2 diabetes and the use thereof. The electuary is prepared by compounding the following components, in percentages by weight: 45% to 90% of sorbitol, 5% to 50% of betaine or betaine hydrochloride, and 0.01% to 10% of Span 60. The sorbitol of the present invention enables the dissolved fat to form a stable emulsion or ultramicroemulsion, and has a molecular structure similar to that of a glucose molecule, can simulate the glucose molecule to play a targeted localization role, and also has a certain sweetness to improve the taste of the electuary. The betaine/betaine hydrochloride is a biosurfactant for helping to dissolve fat, and also has the function of protecting and nourishing the liver, and improves the insulin utilization efficiency. The Span 60 enables the fat on the surface of a deposition channel to dissolve gradually. The electuary of the present invention enables the fat deposited on the surface of the channel and the semipermeable membrane to form a stable "oil-in-water" emulsion or ultramicroemulsion, so that the deposited fat is excreted from the body via the excretory system after dissolution and the insulin utilization efficiency is improved.
Inventors:
CAO CHANGSHENG (CN)
DU YINLONG (CN)
DU SHIRUI (CN)
DU YINLONG (CN)
DU SHIRUI (CN)
Application Number:
PCT/CN2018/081009
Publication Date:
December 06, 2018
Filing Date:
March 29, 2018
Export Citation:
Assignee:
UNIV JIANGSU NORMAL (CN)
International Classes:
A61K31/34; A61K9/16; A61K31/047; A61K31/205; A61P3/10
Foreign References:
| CN106983742A | 2017-07-28 | |||
| CN102197827A | 2011-09-28 |
Other References:
CHENG, RONGYI ET AL.: "Study on Preventive Effect of Betaine on Experimental Hyperlipidemia and Fatty Liver in Mice", CHINA PHARMACIST, vol. 7, no. 6, 30 June 2004 (2004-06-30), pages 411 - 413
WARWICK, J.D. ET AL.: "Elevated Glycine Betaine Excretion in Diabetes Mellitus Patients is Associated with Proximal Tubular Dysfunction and Hyperglycemia", DIABETES RESEARCH AND CLINICAL PRACTICE, 31 December 1999 (1999-12-31), pages 91 - 99, XP055079751
WARWICK, J.D. ET AL.: "Elevated Glycine Betaine Excretion in Diabetes Mellitus Patients is Associated with Proximal Tubular Dysfunction and Hyperglycemia", DIABETES RESEARCH AND CLINICAL PRACTICE, 31 December 1999 (1999-12-31), pages 91 - 99, XP055079751
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