Title:
MULTI-FUNCTIONAL NUCLEIC ACID-BASED ANTI-CANCER DRUG CAPABLE OF TARGETING AND THERAPY, METHOD FOR PREPARING SAME AND ANTI-CANCER COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2013/058482
Kind Code:
A3
Abstract:
The present invention relates to a multi-functional nucleic acid-based anti-cancer drug in which the anti-cancer drug is physically bound to a linear nucleic acid having a thiol group at 5' terminal thereof and then gold nanoparticles and aptamers are chemically bound. The present invention also relates to a method for preparing the anti-cancer drug and to an anti-cancer composition comprising the anti-cancer drug. The multi-functional nucleic acid-based anti-cancer drug according to the present invention uses A10 aptamer to achieve high targeting properties, and uses high-concentration anti-cancer drugs and gold nanoparticles to enable dual therapy of thermal therapy/chemical therapy, and may have less side effects and be more effective in anti-cancer therapy compared to existing anti-cancer drugs.
Inventors:
UM SOONG HO (KR)
KIM A RA (KR)
KIM A RA (KR)
Application Number:
PCT/KR2012/007603
Publication Date:
June 27, 2013
Filing Date:
September 21, 2012
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN RES & BUS (KR)
International Classes:
A61K33/24; A61K49/00; A61P35/00
Foreign References:
| US20110237652A1 | 2011-09-29 | |||
| US20110178161A1 | 2011-07-21 |
Other References:
YU-FEN HUANG ET AL.: "Aptamer-modified gold nanoparticles for targeting breast cancer cells through light scattering.", JOURNAL OF NANOPARTICLE RESEARCH., vol. 11, no. 4, May 2009 (2009-05-01), pages 775 - 783, XP019685122
CHIH-CHING HUANG ET AL.: "Aptamer-Modified Gold Nanoparticles for Colorimetric Determination of Platelet-Derived Growth Factors and Their Receptors.", ANALYTICAL CHEMISTRY, vol. 77, no. 17, 2005, pages 5735 - 5741
CHIH-CHING HUANG ET AL.: "Aptamer-Modified Gold Nanoparticles for Colorimetric Determination of Platelet-Derived Growth Factors and Their Receptors.", ANALYTICAL CHEMISTRY, vol. 77, no. 17, 2005, pages 5735 - 5741
Attorney, Agent or Firm:
ERUUM PATENT LAW FIRM (1005-8 Daechi-dong,,Kangnam-gu, Seoul 135-851, KR)
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Claims: