Title:
MULTI-KINASE INHIBITOR COMPOUND, AND CRYSTAL FORM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/108079
Kind Code:
A1
Abstract:
The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, X, Y, P, W, and Ar are as defined in the description. The compound of formula (I) of the present invention can be used in the preparation of a drug for treating cancers mediated by multi-kinase abnormalities. Also provided is a crystal form I of a compound 4-(5-(2-chlorophenyl)-3-methyl-2,10-dihydropyrazole[4,3-b]pyrido[4,3-e] [1,4]diazepin-8-yl)morpholine, wherein in an X-ray powder diffraction pattern of crystal form I, there are characteristic peaks at 7.4 ± 0.2°, 17.9 ± 0.2°, 18.9 ± 0.2°, 19.4 ± 0.2°, 21.5 ± 0.2°, and 23.7 ± 0.2°.
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Inventors:
WU FRANK (CN)
Application Number:
PCT/CN2017/115698
Publication Date:
June 21, 2018
Filing Date:
December 12, 2017
Export Citation:
Assignee:
NANJING TRANSTHERA BIOSCIENCES CO LTD (CN)
International Classes:
C07D471/14; A61K31/551; A61K45/06; A61P35/00; C07D487/04; C07D491/08; C07D519/00
Foreign References:
| CN1348455A | 2002-05-08 | |||
| CN1251312A | 2000-04-26 |
Other References:
LIU, JINJUN ET AL.: "Pyrazolobenzodiazepines: Part I. Synthesis and SAR of a Potent Class of Kinase Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 20, 21 August 2010 (2010-08-21), pages 5984 - 5987, XP027291095
LIU, JINJUN ET AL.: "Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 2, 15 January 2013 (2013-01-15), pages 259 - 263, XP055510076
See also references of EP 3447056A4
LIU, JINJUN ET AL.: "Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 2, 15 January 2013 (2013-01-15), pages 259 - 263, XP055510076
See also references of EP 3447056A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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