Title:
MULTI-LAYERED ENDOPLASMIC RETICULUM FOR INDUCING IMMUNITY, PHARMACEUTICAL COMPOSITION FOR INDUCING IMMUNITY COMPRISING SAME, AND METHOD FOR PRODUCING MULTI-LAYERED ENDOPLASMIC RETICULUM FOR INDUCING IMMUNITY
Document Type and Number:
WIPO Patent Application WO/2023/022384
Kind Code:
A1
Abstract:
The present invention relates to a multi-layered endoplasmic reticulum for inducing immunity, a pharmaceutical composition for inducing immunity comprising same, and a method for producing a multi-layered endoplasmic reticulum for inducing immunity. The multi-layered endoplasmic reticulum for inducing immunity according to the present invention can stably move into immune cells without chemical bonding, and a pharmaceutical composition for inducing immunity employing same can effectively induce humoral immunity and cellular immunity at the same time, thereby exhibiting an improved immune-inducing effect.
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Inventors:
NAM YOON SUNG (KR)
KOO BON IL (KR)
KOO BON IL (KR)
Application Number:
PCT/KR2022/010963
Publication Date:
February 23, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K9/51; A61K9/127; A61K39/00; A61P37/00
Domestic Patent References:
| WO2016115480A1 | 2016-07-21 |
Foreign References:
| JPH10500662A | 1998-01-20 | |||
| EP2547327B1 | 2018-09-05 |
Other References:
KOO, BON IL: "Multilamellar protein-lipid hybrid nanovesicles for In vivo protein delivery", PH.D. THESIS, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, February 2021 (2021-02-01)
KOO BON IL, KIM INHYE, YANG MOON YOUNG, JO SUNG DUK, KOO KUNMO, SHIN SEO YEON, PARK KYUNG MOK, YUK JONG MIN, LEE EUNJI, NAM YOON S: "Protein-induced metamorphosis of unilamellar lipid vesicles to multilamellar hybrid vesicles", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 331, 1 March 2021 (2021-03-01), AMSTERDAM, NL , pages 187 - 197, XP093036365, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2021.01.004
FAN YUCHEN; SAHDEV PREETY; OCHYL LUKASZ J.; J. AKERBERG JONATHAN; MOON JAMES J.: "Cationic liposome-hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 208, 11 April 2015 (2015-04-11), AMSTERDAM, NL , pages 121 - 129, XP029158899, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2015.04.010
JAMES J. MOON, HEIKYUNG SUH, ANNA BERSHTEYN, MATTHIAS T. STEPHAN, HAIPENG LIU, BONNIE HUANG, MASHAAL SOHAIL, SAMANTHA LUO, SOONG H: "Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses", NATURE MATERIALS, NATURE PUB. GROUP, vol. 10, no. 3, 1 March 2011 (2011-03-01), pages 243 - 251, XP055020205, ISSN: 14761122, DOI: 10.1038/nmat2960
KOO BON IL, JIN SEON‐MI, KIM HAYEON, LEE DONG JAE, LEE EUNJI, NAM YOON SUNG: "Conjugation‐Free Multilamellar Protein‐Lipid Hybrid Vesicles for Multifaceted Immune Responses", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 10, no. 22, 1 November 2021 (2021-11-01), DE , pages 2101239, XP093036364, ISSN: 2192-2640, DOI: 10.1002/adhm.202101239
KOO BON IL, KIM INHYE, YANG MOON YOUNG, JO SUNG DUK, KOO KUNMO, SHIN SEO YEON, PARK KYUNG MOK, YUK JONG MIN, LEE EUNJI, NAM YOON S: "Protein-induced metamorphosis of unilamellar lipid vesicles to multilamellar hybrid vesicles", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 331, 1 March 2021 (2021-03-01), AMSTERDAM, NL , pages 187 - 197, XP093036365, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2021.01.004
FAN YUCHEN; SAHDEV PREETY; OCHYL LUKASZ J.; J. AKERBERG JONATHAN; MOON JAMES J.: "Cationic liposome-hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 208, 11 April 2015 (2015-04-11), AMSTERDAM, NL , pages 121 - 129, XP029158899, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2015.04.010
JAMES J. MOON, HEIKYUNG SUH, ANNA BERSHTEYN, MATTHIAS T. STEPHAN, HAIPENG LIU, BONNIE HUANG, MASHAAL SOHAIL, SAMANTHA LUO, SOONG H: "Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses", NATURE MATERIALS, NATURE PUB. GROUP, vol. 10, no. 3, 1 March 2011 (2011-03-01), pages 243 - 251, XP055020205, ISSN: 14761122, DOI: 10.1038/nmat2960
KOO BON IL, JIN SEON‐MI, KIM HAYEON, LEE DONG JAE, LEE EUNJI, NAM YOON SUNG: "Conjugation‐Free Multilamellar Protein‐Lipid Hybrid Vesicles for Multifaceted Immune Responses", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 10, no. 22, 1 November 2021 (2021-11-01), DE , pages 2101239, XP093036364, ISSN: 2192-2640, DOI: 10.1002/adhm.202101239
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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