Title:
MULTI-PH BUFFER FORMULATION AND UREASE ACTIVITY INHIBITOR COMPOSITION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/019758
Kind Code:
A1
Abstract:
A urease activity inhibitor composition, comprising: at least one acid component, at least one alkali component and a urease activity inhibitor, the at least one acid component being one of an organic acid, a phosphoric acid and a combination thereof, the at least one alkali component being one of an organic alkali, a phosphate base and a combination thereof, the at least one acid component and the at least one alkali component having a conjugated relationship, the at least one acid component and the at least one alkali component forming a buffer formulation, the urease activity inhibitor being one of ascorbic acid, an ascorbic acid salt and a combination thereof, the buffer formulation being used to stabilise the activity of the urease inhibitor.
Inventors:
SHEN TA-LU (CN)
CHEN FU-AN (CN)
CHEN FU-AN (CN)
Application Number:
PCT/CN2018/085459
Publication Date:
January 31, 2019
Filing Date:
May 03, 2018
Export Citation:
Assignee:
ECO GEO BIO TECH COMPANY LIMITED (CN)
International Classes:
A23C9/158; C01B25/22; C05C9/00; C05G3/90
Other References:
BARBARA KRAJEWSKA: "Urease Activity and L-Ascorbic Acid", JOUMAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, XP055595216
TAKESHI CHIYODA: "Screening System for Urease Inhibitors Using 13C-NMR", CHEM. PHARM. BULL., vol. 46, 30 April 1998 (1998-04-30), pages 4, XP055595223
P. SESHAGIRI RAO: "Interaction of Vitamin C and Urease", PROCEEDING OF THE INDIAN ACADEMY OF SCIENCES, vol. 35, 31 March 1952 (1952-03-31), XP055677871
L. W. MAPSON: "Inhibition of Urease by Copper Salts in the Presence of Asco- rbic Acid and Related Substances", BIOCHEM J, vol. 40, 31 December 1946 (1946-12-31), pages 240 - 247, XP055677876, DOI: 10.1042/bj0400240
TAKESHI CHIYODA: "Screening System for Urease Inhibitors Using 13C-NMR", CHEM. PHARM. BULL., vol. 46, 30 April 1998 (1998-04-30), pages 4, XP055595223
P. SESHAGIRI RAO: "Interaction of Vitamin C and Urease", PROCEEDING OF THE INDIAN ACADEMY OF SCIENCES, vol. 35, 31 March 1952 (1952-03-31), XP055677871
L. W. MAPSON: "Inhibition of Urease by Copper Salts in the Presence of Asco- rbic Acid and Related Substances", BIOCHEM J, vol. 40, 31 December 1946 (1946-12-31), pages 240 - 247, XP055677876, DOI: 10.1042/bj0400240
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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