MULTI-PHOTON MICROSCOPY, AND IMAGING METHOD USING TIME-GATED DETECTION THEREOF

WIPO Patent Application WO/2021/210768

A1

Multi-photon microscopy and an imaging method using time-gated detection thereof are disclosed. Multi-photon microscopy for exciting the fluorescent material of a sample by using multi-photon excitation comprises: a repetition rate tuner for lowering, to a repetition rate for time-gated detection, an optical pulse stream outputted from a pulsed laser; a scanner for scanning, in X-axis and Y-axis directions, the optical pulse stream received from the repetition rate tuner; an objective lens for emitting an optical signal scanned by the scanner to the sample, and acquiring a fluorescence signal emitted from an excited fluorescent material; a photodetector for photoelectrically converting the fluorescence signal acquired through the objective lens; an amplifier for converting, into a voltage signal, a current signal outputted from the photodetector; a digitizer for sampling the voltage signal outputted from the amplifier; and a computing device for separating, by means of a detection window set in a time domain, sampling data outputted from the digitizer, and generating an image on the basis of the sampling data separated by means of the detection window.

YOO HONGKI (KR)
KIM WOOSEOP (KR)
KANG JUEHYUNG (KR)
KANG UNGYO (KR)

PCT/KR2021/001434

October 21, 2021

February 03, 2021

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KOREA ADVANCED INST SCI & TECH (KR)

G02B21/00; G01N21/64

US20080100834A1	2008-05-01
KR20160014340A	2016-02-11
KR20110112347A	2011-10-12
JP2010008082A	2010-01-14
JP2008216996A	2008-09-18

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