Title:
MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
Document Type and Number:
WIPO Patent Application WO2005115448
Kind Code:
A3
Abstract:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25°C (and immunogenic compositions comprising the same) is also provided.
Inventors:
HOFFMANN ERICH (US)
JIN HONG (US)
LU BIN (US)
DUKE GREGORY (US)
KEMBLE GEORGE (US)
CHEN ZHONGYING (US)
JIN HONG (US)
LU BIN (US)
DUKE GREGORY (US)
KEMBLE GEORGE (US)
CHEN ZHONGYING (US)
Application Number:
PCT/US2005/017734
Publication Date:
December 07, 2006
Filing Date:
May 20, 2005
Export Citation:
Assignee:
MEDIMMUNE VACCINES INC (US)
HOFFMANN ERICH (US)
JIN HONG (US)
LU BIN (US)
DUKE GREGORY (US)
KEMBLE GEORGE (US)
CHEN ZHONGYING (US)
HOFFMANN ERICH (US)
JIN HONG (US)
LU BIN (US)
DUKE GREGORY (US)
KEMBLE GEORGE (US)
CHEN ZHONGYING (US)
International Classes:
C12N7/02; A61K39/12; A61K39/145; C07K14/11; C12N7/00; C12N7/04; C12P19/34
Other References:
SUBBARAO ET AL: "Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.", JOURNAL OF VIROLOGY, vol. 67, no. 12, December 1993 (1993-12-01), pages 7223 - 7228, XP003003961
See also references of EP 1748790A4
See also references of EP 1748790A4
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