Title:
MULTI-SUBSTITUTED URACIL DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/125792
Kind Code:
A1
Abstract:
The present invention relates to a multi-substituted uracil derivative and a preparation method therefor and an application thereof. Specifically, the compound of the present invention has a structure as shown in formula (I) in which the definitions of groups and substituents are as stated in the description. Further disclosed in the present invention is a preparation method for the compound and a use of the compound in antithrombotic, treatment of cardiovascular and cerebrovascular diseases, etc.
Inventors:
QI YOUMAO (CN)
Application Number:
PCT/CN2022/143340
Publication Date:
July 06, 2023
Filing Date:
December 29, 2022
Export Citation:
Assignee:
HANGZHOU ADAMERCK PHARMLABS INC (CN)
International Classes:
C07D239/545; A61K31/513; A61P7/02; A61P9/10; A61P25/00; C07D239/48; C07D239/56; C07D401/06; C07D401/14
Domestic Patent References:
| WO2001038309A1 | 2001-05-31 |
Foreign References:
| CN105473576A | 2016-04-06 | |||
| CN1351594A | 2002-05-29 | |||
| US20030207882A1 | 2003-11-06 | |||
| US20030023086A1 | 2003-01-30 | |||
| CN108299313A | 2018-07-20 | |||
| CN102652023A | 2012-08-29 | |||
| CN104024241A | 2014-09-03 | |||
| US4250183A | 1981-02-10 | |||
| US6022869A | 2000-02-08 |
Other References:
KANAOKA YOSHITOMO, IKEUCHI YOSHIHIRO, KAWAMOTO TETSUJI, BESSHO KIYOSHI, AKIMOTO NAOSHIGE, MIKATA YUJI, NISHIDA MAMIKO, YANO SHIGEN: "Synthesis and Evaluation of Nitro 5-Deaza¯avinpyrrolecarboxamide(s) Hybrid Molecules as Novel DNA Targeted Bioreductive Antitumor Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1 January 1998 (1998-01-01), pages 301 - 314, XP093076104
TOLAN HALA E. M., EL-SAYED WAEL A., TAWFEK NASHWA, ABDEL-MEGEID FAROUK M. E., KUTKAT OMNYA M.: "Synthesis and anti-H5N1 virus activity of triazole- and oxadiazole-pyrimidine hybrids and their nucleoside analogs", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, TAYLOR & FRANCIS, US, vol. 39, no. 5, 3 May 2020 (2020-05-03), US , pages 649 - 670, XP093076105, ISSN: 1525-7770, DOI: 10.1080/15257770.2019.1674331
TOLAN HALA E. M., EL-SAYED WAEL A., TAWFEK NASHWA, ABDEL-MEGEID FAROUK M. E., KUTKAT OMNYA M.: "Synthesis and anti-H5N1 virus activity of triazole- and oxadiazole-pyrimidine hybrids and their nucleoside analogs", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, TAYLOR & FRANCIS, US, vol. 39, no. 5, 3 May 2020 (2020-05-03), US , pages 649 - 670, XP093076105, ISSN: 1525-7770, DOI: 10.1080/15257770.2019.1674331
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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