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Title:
MULTI-TARGET CHIMERIC ANTIGEN RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2018/121604
Kind Code:
A1
Abstract:
Disclosed in the present invention is a multi-target chimeric antigen receptor. Provided in the present invention is a multi-target chimeric antigen receptor consisting of a main peptide chain and an auxiliary peptide chain; the main peptide chain comprises an antigen binding domain A, an auxiliary peptide chain connecting domain B, a transmembrane domain C and an intracellular signaling domain D; the auxiliary peptide chain comprises a main peptide chain connecting domain F; the antigen binding domain A is a polypeptide having an antigen-binding function; the auxiliary chain connecting domain B and the main peptide connecting domain F are combined with each other; the transmembrane domain C is a transmembrane domain of any membrane-binding protein or a transmembrane protein; and the intracellular signaling domain D comprises a primary signaling region. The multi-target chimeric antigen receptor of the present invention can bind to different antigens through the two antigen binding domains thereof, and mediates specific cell killing; and a cytokine and cytokine receptor complex playing the role of a cytokine are introduced into the multi-target chimeric antigen receptor of the present invention.

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Inventors:
WANG LEI (CN)
GAO BIN (CN)
WU YASONG (CN)
SI YUAN (CN)
LV DAN (CN)
WEI QING (CN)
Application Number:
PCT/CN2017/118980
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
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Assignee:
TIMMUNE BIOTECH INC (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C12N5/10; C12N15/62; C12N15/63; G01N33/68
Domestic Patent References:
WO2013123061A12013-08-22
WO2016120216A12016-08-04
Foreign References:
CN105392888A2016-03-09
CN201280037114A2012-06-22
CN201510358540A2011-09-21
CN201710005395A2017-01-04
CN201510733585A2015-11-02
CN201710640609A2017-07-31
CN201610353118A2016-05-26
CN200380109929A2003-12-22
CN201310258289A2013-06-26
CN201180019629A2011-03-09
Other References:
GRADA, Z. ET AL.: "TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy", MOLECULAR THERAPY-NUCLEIC ACIDS, vol. 2, no. eI05, 9 July 2013 (2013-07-09), XP055485878
See also references of EP 3575325A4
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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