Title:
MULTI-TARGET COMPOUND WITH ANTICOAGULATION AND ANTIPLATELET ACTIVITY, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/020282
Kind Code:
A1
Abstract:
Provided is a multi-target compound with anticoagulation and platelet GPIIb/IIIa receptor antagonism. The formula of the multi-target compound is as follows: A-L-B-L'-C. A and B are binding sites with a thrombin, C is a binding site with a platelet GPIIb/IIIa receptor, L is a first linking group, and L' is a second linking group. Also provided are a preparation method for the compound and use of the compound. The compound has the effects on inhibiting human thrombin activity and a platelet GPIIb/IIIa receptor in vitro, and has the effects on anti-platelet aggregation in vitro/in vivo, and anticoagulation and antithrombosis in vivo.
Inventors:
FAN QIANGWEI (CN)
Application Number:
PCT/CN2015/086173
Publication Date:
February 09, 2017
Filing Date:
August 05, 2015
Export Citation:
Assignee:
SHAANXI MICOT TECH LTD COMPANY (CN)
International Classes:
C07K9/00; A61K38/16; A61P7/02; A61P9/10
Domestic Patent References:
| WO2003090733A1 | 2003-11-06 |
Foreign References:
| CN101284877A | 2008-10-15 |
Other References:
See also references of EP 3333177A4
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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