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Title:
MULTI-TRANSPOSON SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/060589
Kind Code:
A1
Abstract:
Provided in the present disclosure is a method for integrating one or more exogenous nucleotide sequences into a host cell genome of a mammal. The method comprises integrating the one or more exogenous nucleotide sequences into the host cell genome of the mammal using at least two transposon systems.

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Inventors:
XUE BOFU (CN)
YANG YINHUI (CN)
LIU JIE (CN)
CHEN LI (CN)
Application Number:
PCT/CN2021/124202
Publication Date:
April 20, 2023
Filing Date:
October 15, 2021
Export Citation:
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Assignee:
SHENZHEN EUREKA BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/10; C12N15/85; C12N7/00; C12N15/67; C12R1/93
Domestic Patent References:
WO2021146666A22021-07-22
Foreign References:
CN109312365A2019-02-05
CN108474005A2018-08-31
US20190185863A12019-06-20
Other References:
JIN TAO, WU SHA, ZHANG XIN, XU LIJIA, OSCAR ORTEGON, YE QIN, LI YUN: "Advance of Tol1 Transposable Element Study", BIOTECHNOLOGY BULLETIN, no. 5, 26 May 2012 (2012-05-26), pages 38 - 41, XP093058679, ISSN: 1002-5464, DOI: 10.13560/j.cnki.biotech.bull.1985.2012.05.028
SARIDEY SAI K, LIU LI, DOHERTY JOSEPH E, KAJA APARNA, GALVAN DANIEL L, FLETCHER BRADLEY S, WILSON MATTHEW H: "PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 17, no. 12, 6 October 2009 (2009-10-06), US , pages 2115 - 2120, XP055844358, ISSN: 1525-0016, DOI: 10.1038/mt.2009.234
Attorney, Agent or Firm:
SHENZHEN ZHONGYI UNION INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)
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