Title:
MULTIBLOCK BIODEGRADABLE HYDROGELS FOR USE AS CONTROLLED RELEASE AGENTS FOR DRUGS DELIVERY AND TISSUE TREATMENT AGENTS
Document Type and Number:
WIPO Patent Application WO1997005185
Kind Code:
A3
Abstract:
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
Inventors:
PATHAK CHANDRASHEKHAR P
BARMAN SHIKHA P
PHILBROOK C MICHAEL
SAWHNEY AMARPREET
COURY ARTHUR J
AVILA LUIS Z
KIERAS MARK T
BARMAN SHIKHA P
PHILBROOK C MICHAEL
SAWHNEY AMARPREET
COURY ARTHUR J
AVILA LUIS Z
KIERAS MARK T
Application Number:
PCT/US1996/012285
Publication Date:
March 13, 1997
Filing Date:
July 26, 1996
Export Citation:
Assignee:
FOCAL INC (US)
International Classes:
A61K9/00; A61K9/127; C08G65/32; A61K9/14; A61K9/20; A61K9/51; A61K9/70; A61K38/17; A61K47/32; A61K47/34; A61K48/00; A61L15/58; A61L15/60; A61L24/00; A61L24/04; C08F299/02; C08G18/40; C08G63/00; C08G63/672; C08G65/329; C08L71/02; A61K9/107; (IPC1-7): C08G63/664; C08G65/32; A61K9/00
Foreign References:
| US5410016A | 1995-04-25 | |||
| EP0108933A1 | 1984-05-23 | |||
| DE1595369A1 | 1970-04-09 | |||
| EP0552802A2 | 1993-07-28 | |||
| US4716203A | 1987-12-29 |
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