Title:
MULTICYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
Document Type and Number:
WIPO Patent Application WO2000043354
Kind Code:
A3
Abstract:
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
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Inventors:
GRANT FRANCINE S (US)
JOHNSON BRADLEY S (US)
PLEISS MICHAEL A (US)
THORSETT EUGENE D (US)
JOHNSON BRADLEY S (US)
PLEISS MICHAEL A (US)
THORSETT EUGENE D (US)
Application Number:
PCT/US2000/001604
Publication Date:
November 23, 2000
Filing Date:
January 21, 2000
Export Citation:
Assignee:
ELAN PHARM INC (US)
GRANT FRANCINE S (US)
JOHNSON BRADLEY S (US)
PLEISS MICHAEL A (US)
THORSETT EUGENE D (US)
GRANT FRANCINE S (US)
JOHNSON BRADLEY S (US)
PLEISS MICHAEL A (US)
THORSETT EUGENE D (US)
International Classes:
A61K31/192; A61K31/216; C07D295/20; A61K31/42; A61K31/426; A61K31/4418; A61K31/495; A61K31/54; A61P1/00; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; C07C233/63; C07C237/22; C07C255/60; C07C271/22; C07C271/42; C07C271/44; C07C275/16; C07C275/20; C07D213/55; C07D213/64; C07D213/80; C07D213/89; C07D239/52; C07D239/54; C07D261/08; C07D277/28; C07D277/48; C07D295/15; C07D295/205; C07D453/02; (IPC1-7): C07C233/63; A61K31/16
Domestic Patent References:
| WO1996001644A1 | 1996-01-25 | |||
| WO1999064390A1 | 1999-12-16 | |||
| WO1999010313A1 | 1999-03-04 |
Foreign References:
| US5770573A | 1998-06-23 | |||
| US5821231A | 1998-10-13 |
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