Title:
MULTIFUNCTIONAL COMPOUND CAPABLE OF DEGRADING BTK KINASE, AND COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2023/088477
Kind Code:
A1
Abstract:
Disclosed in the present invention are a Bruton's tyrosine kinase degrading agent, which has a structure represented by general formula I; or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt and a prodrug thereof. Further disclosed are the uses of the compound and a pharmaceutical composition containing same in the preparation of a drug for treating Bruton's tyrosine kinase-related diseases such as B cell or plasma cell proliferative diseases. The compound of the present invention has potent cell proliferation inhibitory activity, effectively degrades Bruton's tyrosine kinase, and has a good liver particle metabolism stability and good oral absorption properties. The compound can be used alone in drugs or in combination with other drugs for treating a disease, disorder or condition that benefits from the inhibition of the Bruton's tyrosine kinase activity or degradation of the Bruton's tyrosine kinase.
Inventors:
ZHOU XINGLU (CN)
LI JIA (CN)
LIU XINGGUO (CN)
ZHOU YUBO (CN)
HU MIAO (CN)
LUO XIAOMIN (CN)
XIE JIANGFENG (CN)
KAN WEIJUAN (CN)
WU YIZHE (CN)
HU XIAOBEI (CN)
SU MINGBO (CN)
LI JIA (CN)
LIU XINGGUO (CN)
ZHOU YUBO (CN)
HU MIAO (CN)
LUO XIAOMIN (CN)
XIE JIANGFENG (CN)
KAN WEIJUAN (CN)
WU YIZHE (CN)
HU XIAOBEI (CN)
SU MINGBO (CN)
Application Number:
PCT/CN2022/133404
Publication Date:
May 25, 2023
Filing Date:
November 22, 2022
Export Citation:
Assignee:
HANGZHOU HEALZEN THERAPEUTICS CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/4427; C07D401/14; A61K31/497; A61K31/5377; A61P35/00; A61P37/00; C07D413/14; C07D417/14; C07D471/04; C07D471/10; C07D487/04; C07D487/10
Domestic Patent References:
| WO2021113557A1 | 2021-06-10 |
Foreign References:
| CN113412259A | 2021-09-17 | |||
| CN111285851A | 2020-06-16 | |||
| CN110483521A | 2019-11-22 | |||
| CN109563076A | 2019-04-02 | |||
| CN105777759A | 2016-07-20 |
Attorney, Agent or Firm:
HANGZHOU ZHIXIAN PATENT AGENCY (CN)
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