Title:
MULTIFUNCTIONAL NUCLEIC ACID STRUCTURE FOR TARGET GENE MODULATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/225353
Kind Code:
A1
Abstract:
The present application relates to a multifunctional nucleic acid structure for target gene modulation and uses thereof, wherein a structure according to one example is capable of both effectively reducing the expression of a first target gene, as well as additionally modulating selective splicing, degrading mRNA of a second target gene, and/or inhibiting miRNA action.
Inventors:
LEE HYUKJIN (KR)
KIM HYUNSOOK (KR)
JANG BORA (KR)
KIM HYUNSOOK (KR)
JANG BORA (KR)
Application Number:
PCT/KR2022/005736
Publication Date:
October 27, 2022
Filing Date:
April 21, 2022
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
C12N15/113; C12N15/10
Domestic Patent References:
| WO2019161449A1 | 2019-08-29 |
Foreign References:
| KR20170082534A | 2017-07-14 |
Other References:
CHIU YA-LIN, RANA TARIQ M.: "siRNA function in RNAi: A chemical modification analysis", RNA, vol. 9, no. 9, 1 September 2003 (2003-09-01), COLD SPRING HARBOR LABORATORY PRESS, US, pages 1034 - 1048, XP055959923, ISSN: 1355-8382, DOI: 10.1261/rna.5103703
BOFILL-DE ROS, XAVIER, WOJCIECH K. KASPRZAK, YUBA BHANDARI, LIXIN FAN, QUINN CAVANAUGH, MINJIE JIANG, LISHENG DAI, ACONG YANG, TIE: " Structural differences between Pri-miRNA paralogs promote alternative drosha cleavage and expand target repertoires. ", CELL REPORTS, vol. 26, no. 2, 8 January 2019 (2019-01-08), pages 447-459, e1 - e4, XP055978504, DOI: 10.1016/j.celrep.2018.12.054
JAN STENVANG, ANDREAS PETRI, MORTEN LINDOW, SUSANNA OBAD, SAKARI KAUPPINEN: "Inhibition of microRNA function by antimiR oligonucleotides", SILENCE, BIOMED CENTRAL, vol. 3, no. 1, 1 January 2012 (2012-01-01), pages 1 - 17, XP055215128, ISSN: 1758-907X, DOI: 10.1186/1758-907X-3-1
BOFILL-DE ROS, XAVIER, WOJCIECH K. KASPRZAK, YUBA BHANDARI, LIXIN FAN, QUINN CAVANAUGH, MINJIE JIANG, LISHENG DAI, ACONG YANG, TIE: " Structural differences between Pri-miRNA paralogs promote alternative drosha cleavage and expand target repertoires. ", CELL REPORTS, vol. 26, no. 2, 8 January 2019 (2019-01-08), pages 447-459, e1 - e4, XP055978504, DOI: 10.1016/j.celrep.2018.12.054
JAN STENVANG, ANDREAS PETRI, MORTEN LINDOW, SUSANNA OBAD, SAKARI KAUPPINEN: "Inhibition of microRNA function by antimiR oligonucleotides", SILENCE, BIOMED CENTRAL, vol. 3, no. 1, 1 January 2012 (2012-01-01), pages 1 - 17, XP055215128, ISSN: 1758-907X, DOI: 10.1186/1758-907X-3-1
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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