Title:
MULTIFUNCTIONAL POLYOXYALKYLENE COMPOUND, METHOD FOR PRODUCING SAME AND INTERMEDIATE OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/125786
Kind Code:
A1
Abstract:
Disclosed is a multifunctional polyoxyalkylene compound which is formed by stable bonds and is not easily decomposed to a single chain, while having no asymmetric carbon atom in the core skeleton.
Specifically disclosed is a multifunctional polyoxyalkylene compound represented by formula (1).
(In the formula, Z represents a dehydroxylated residue of pentaerythritol or dipentaerythritol; R represents a hydrocarbon group having 1-24 carbon atoms; OA1 and OA2 each represents an oxyalkylene group having 2-4 carbon atoms; L1 and L2 each represents an alkylene group which may have an ester bond or the like in the alkylene chain or at an end; X represents a chemically reactive functional group; R, OA1, OA2, L1 and L2 may be the same as or different from each other in each molecule; m and n each represents an average mole number of added oxyalkylene groups, with m being a number of 5-1,000 and n being a number of 0-1,000; p and q each represents 0 or 1; and r1 + r2 = 4 or 6, with r1 and r2 each being an integer of 2 or more.)
Inventors:
NAKAMOTO KEN-ICHIRO
KAMIYA MASAKI
TAKEHANA TSUYOSHI
KAMIYA MASAKI
TAKEHANA TSUYOSHI
Application Number:
PCT/JP2011/058110
Publication Date:
October 13, 2011
Filing Date:
March 30, 2011
Export Citation:
Assignee:
NOF CORP (JP)
NAKAMOTO KEN-ICHIRO
KAMIYA MASAKI
TAKEHANA TSUYOSHI
NAKAMOTO KEN-ICHIRO
KAMIYA MASAKI
TAKEHANA TSUYOSHI
International Classes:
C08G65/329; C08G65/28
Domestic Patent References:
| WO2008066902A2 | 2008-06-05 | |||
| WO1999045964A1 | 1999-09-16 | |||
| WO2005061005A2 | 2005-07-07 | |||
| WO1999045964A1 | 1999-09-16 |
Foreign References:
| JP2003113241A | 2003-04-18 | |||
| JPH0848764A | 1996-02-20 | |||
| JP2010053026A | 2010-03-11 | |||
| JP2008133245A | 2008-06-12 | |||
| JPH02242823A | 1990-09-27 | |||
| JPH09510489A | 1997-10-21 | |||
| US6153655A | 2000-11-28 | |||
| US6251382B1 | 2001-06-26 | |||
| US6824766B2 | 2004-11-30 |
Other References:
ZENG, F. ET AL.: "Synthesis and Characterization of Six-Arm Star Poly(5-valerolactone)-block- Methoxy Poly(ethylene glycol) Copolymers", BIOMACROMOLECULES, vol. 6, no. 4, 2005, pages 2140 - 2149, XP002519230
HE, E. ET AL.: "Binding and release studies of a cationic drug from a star-shaped four-arm poly (ethylene oxide)-b-poly(methacrylic acid)", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99, no. 2, 2010, pages 782 - 793, XP055124962
J. MILTON HARRIS; GREG T. HERMANSON: "Bioconjugate Techniques second edition", 2008, article "POLY(ETYLENE GLYCOL)CHEMISTRY"
FRANCESCO M. VERONESE, PEGYLATED PROTEIN DRUG: BASIC SCIENCE AND CLINICAL APPLICATION, 2009
See also references of EP 2554565A4
HE, E. ET AL.: "Binding and release studies of a cationic drug from a star-shaped four-arm poly (ethylene oxide)-b-poly(methacrylic acid)", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99, no. 2, 2010, pages 782 - 793, XP055124962
J. MILTON HARRIS; GREG T. HERMANSON: "Bioconjugate Techniques second edition", 2008, article "POLY(ETYLENE GLYCOL)CHEMISTRY"
FRANCESCO M. VERONESE, PEGYLATED PROTEIN DRUG: BASIC SCIENCE AND CLINICAL APPLICATION, 2009
See also references of EP 2554565A4
Attorney, Agent or Firm:
NAITO TERUO (JP)
Teruo Naito (JP)
Teruo Naito (JP)
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