Title:
MULTILAMELLAR LIPID VESICLE COMPOSITIONS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2016/040887
Kind Code:
A3
Abstract:
The present invention provides novel and inventive drug delivery systems with higher loading capability, a capacity to sequester high levels of both hydrophobic and hydrophilic agents simultaneously, and longer release profiles. Some aspects of these delivery systems include compositions including stabilized multilamellar lipid vesicles having crosslinked lipid bilayers (referred to herein as interbilayer-crosslinked multilamellar vesicles or ICMV) covalently conjugated to an agent (e.g., an antigen).
Inventors:
LI ADRIENNE (US)
EBY JACKSON (US)
DEMUTH PETER C (US)
EBY JACKSON (US)
DEMUTH PETER C (US)
Application Number:
PCT/US2015/049819
Publication Date:
June 02, 2016
Filing Date:
September 11, 2015
Export Citation:
Assignee:
VEDANTRA PHARMACEUTICALS INC (US)
International Classes:
A61K31/56; A61K9/127
Foreign References:
| US20120177724A1 | 2012-07-12 | |||
| US20120171290A1 | 2012-07-05 | |||
| US20100120700A1 | 2010-05-13 |
Other References:
LA PORTA, RF ET AL.: "Human Papilloma Viral DNA Replicates as a Stable Episome in Cultured Epidermal Keratinocytes.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 79, no. 11, June 1982 (1982-06-01), USA, pages 3393 - 3397, XP055416847
Attorney, Agent or Firm:
BIEKER-BRADY, Kristina et al. (101 Federal Street15th Floo, Boston MA, US)
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