MULTIMERIC PROTEINS AND METHODS OF MAKING AND USING SAME

WIPO Patent Application WO2003062370

A3

The invention provides multimerization polypeptides capable of conferring formation of multimers when the multimerization polypeptide is linked to a molecule, such as a heterologous polypeptide sequence.

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FANG FANG (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHRINE HELEN (US)

PCT/US2002/023003

December 15, 2005

July 19, 2002

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PERLAN THERAPEUTICS INC (US)
FANG FANG (US)
LUO GUANG-XIANG (US)
KOHLSTAEDT LORI ALLISON (US)
CHARLES CATHRINE HELEN (US)

A61K39/395; A61P11/00; C12N15/09; A61P11/06; A61P25/06; A61P27/16; A61P29/00; C07K14/00; C07K14/47; C07K14/475; C07K14/705; C07K16/18; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N15/62; C12P21/02; C12P21/04; A61K38/00; (IPC1-7): A61K38/00; C07K14/00; C07K16/00

HARBURY P. ET AL.: "A Switch Between Two-,Three-,and Four-Stranded Coiled Coils in GCN4 Leucine Zipper Mutants.", SCIENCE, vol. 262, 26 November 1993 (1993-11-26), pages 1401 - 1407, XP000941971
PESCINI R. ET AL.: "ATF-AO, a Novel Variant of the ATF/CREB Transcription Factor Family Forms a Dominant Transcription Inhibitor in ATF-a Heterodimers.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 2, 4 January 1994 (1994-01-04), pages 1159 - 1166, XP002990755

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